SLC6A1
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Official Full Name
solute carrier family 6 (neurotransmitter transporter), member 1 -
Overview
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009] -
Synonyms
SLC6A1;solute carrier family 6 (neurotransmitter transporter), member 1;GAT1;GABATR;GABATHG;sodium- and chloride-dependent GABA transporter 1;GAT-1;GABA transporter 1;solute carrier family 6 member 1;solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- His&Fc&Avi
Involved Pathway
SLC6A1 involved in several pathways and played different roles in them. We selected most pathways SLC6A1 participated on our site, such as GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | GLUL,GABRA4,SLC38A3,GNG2,SLC38A5,PRKACB,GNG13,PRKCG,GAD2,GABRD |
Protein Function
SLC6A1 has several biochemical functions, for example, gamma-aminobutyric acid:sodium symporter activity,neurotransmitter:sodium symporter activity,symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A1 itself. We selected most functions SLC6A1 had, and list some proteins which have the same functions with SLC6A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| symporter activity | SLC5A4,SLC20A1B,SLC6A20A,SLC16A1,SLC1A3A,SLC6A11A,SLC17A7,SLC1A2A,SLC6A16B,SLC1A7A |
| neurotransmitter:sodium symporter activity | SLC6A1A,SLC6A19B,SLC6A17,SLC6A20A,SLC6A9,SLC6A13L,SLC6A20,SLC6A2,SLC6A8,SLC6A16B |
| gamma-aminobutyric acid:sodium symporter activity | SLC6A13,SLC6A1B,SLC6A11,SLC6A12,SLC6A13L,SLC6A11A,SLC6A1A |
Interacting Protein
SLC6A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A1.
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References
- Tritsch, NX; Oh, WJ; et al. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. ELIFE 3:-(2014).
- Dikow, N; Maas, B; et al. 3p25.3 Microdeletion of GABA Transporters SLC6A1 and SLC6A11 Results in Intellectual Disability, Epilepsy and Stereotypic Behavior. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3061-3068(2014).
