SLC5A12
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Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 12 -
Overview
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of;lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal;tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule;(Gopal et al., 2007 (PubMed 17692818)). -
Synonyms
SLC5A12;solute carrier family 5 (sodium/glucose cotransporter), member 12;sodium-coupled monocarboxylate transporter 2;MGC52019;solute carrier family 5 member 12;sodium-iodide related cotransporter;low-affinity sodium-lactate cotransporter;electron
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| SLC5A12-10688Z | Recombinant Zebrafish SLC5A12 | Mammalian Cell | Zebrafish | His |
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| SLC5A12-15481M | Recombinant Mouse SLC5A12 Protein | Mammalian Cell | Mouse | His |
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| SLC5A12-23H | Recombinant Human solute carrier family 5 member 12 Protein, His6ABP tagged | E. coli | Human | N-His&ABP |
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| SLC5A12-8398M | Recombinant Mouse SLC5A12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC5A12-8398M-B | Recombinant Mouse SLC5A12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC5A12 involved in several pathways and played different roles in them. We selected most pathways SLC5A12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC5A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SLC5A12 has several biochemical functions, for example, lactate transmembrane transporter activity,symporter activity,transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC5A12 itself. We selected most functions SLC5A12 had, and list some proteins which have the same functions with SLC5A12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lactate transmembrane transporter activity | SLC16A3,SLC16A8,SLC16A5,SLC16A12B,SLC16A12,SLC16A7,SLC16A1 |
| symporter activity | SLC10A7,SLC6A6,SLC17A6A,SLC15A3,SLC16A12B,SLC23A2,SLC24A4,MFSD2AB,SLC6A19B,SLC15A4 |
| transporter activity | MUP3,HIAT1B,SLC6A20B,RLBP1,RLBP1A,SCARB1,IGF2R,AQP1A.2,VPS9D1,APODA.1 |
Interacting Protein
SLC5A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC5A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC5A12.
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References
- Gopal, E; Umapathy, NS; et al. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1768:2690-2697(2007).
