SLC4A11
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Official Full Name
solute carrier family 4, sodium borate transporter, member 11 -
Overview
This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. -
Synonyms
SLC4A11;solute carrier family 4, sodium borate transporter, member 11;CDPD1, CHED2, corneal dystrophy and perceptive deafness 1 , corneal endothelial dystrophy 2 (autosomal recessive) , solute carrier family 4, sodium bicarbonate transporter like, me
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC4A11-15467M | Recombinant Mouse SLC4A11 Protein | Mammalian Cell | Mouse | His |
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| SLC4A11-7433Z | Recombinant Zebrafish SLC4A11 | Mammalian Cell | Zebrafish | His |
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| SLC4A11-8388M | Recombinant Mouse SLC4A11 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC4A11-8388M-B | Recombinant Mouse SLC4A11 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC4A11 involved in several pathways and played different roles in them. We selected most pathways SLC4A11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SLC4A11 has several biochemical functions, for example, anion transmembrane transporter activity,anion:anion antiporter activity,bicarbonate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A11 itself. We selected most functions SLC4A11 had, and list some proteins which have the same functions with SLC4A11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| symporter activity | SLC1A3A,SLC16A12B,SLC15A4,SLC17A8,SLC20A1B,SLC38A1,SLC6A18,SLC24A5,SLC6A1A,SLC17A7 |
| inorganic anion exchanger activity | SLC4A3,SLC22A12,SLC4A1,SLC4A1B,SLC4A4A,SLC22A24,SLC22A8,SLC4A4,SLC22A9,SLC22A20 |
| anion:anion antiporter activity | SLC4A2B,SLC4A1B,SLC26A2,SLC26A7,SLC26A3,SLC26A9,SLC4A2A,SLC4A8,SLC4A1,SLC26A3.2 |
| protein dimerization activity | MTOR,POLR2J2,MGAA,MESPBA,FERD3L,HER11,MITFB,LDB1A,ZBED6,HEY1 |
| anion transmembrane transporter activity | SLC4A2B,SLC4A1,SLC4A2A,SLC4A8,SLC4A1B,SLC4A1A,SLC26A11,Slc4a2,ABCA1,SLC4A4A |
| transporter activity | SLC5A11,CRABP2,AQP3B,ATP5O,SEC14L3,ATP6V1C1,SEC22A,ABCA6,HIATL1,IGF2R |
| hydrogen ion channel activity | NOX5,ASIC5,ACCN5 |
| sodium channel activity | ASIC3,ACCN4,SCN4AA,ACCN3,SCN11A,ASIC4A,SCN8AB,TRPM2,KCNK1,SCN1LAB |
| bicarbonate transmembrane transporter activity | CFTR,SLC26A4,SLC26A11,SLC26A3.2,SLC4A1,SLC26A2,SLC26A7,SLC4A1B,SLC26A5,SLC26A1 |
Interacting Protein
SLC4A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A11.
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References
- Minear, MA; Li, YJ; et al. Genetic screen of African Americans with Fuchs endothelial corneal dystrophy. MOLECULAR VISION 19:2508-2516(2013).
- Kodaganur, SG; Kapoor, S; et al. Mutation analysis of the SLC4A11 gene in Indian families with congenital hereditary endothelial dystrophy 2 and a review of the literature. MOLECULAR VISION 19:1694-1706(2013).
