SLC46A1
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Official Full Name
solute carrier family 46 (folate transporter), member 1 -
Overview
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
SLC46A1;solute carrier family 46 (folate transporter), member 1;solute carrier family 46, member 1;proton-coupled folate transporter;HCP1;heme carrier protein 1;MGC9564;PCFT;proton coupled folate transporter;G21;PCFT/HCP1;solute carrier family 46 member 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- His
- His&Flag&MBP
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC46A1-2773H | Recombinant Human SLC46A1, His-tagged | E.coli | Human | His | 1-100aa | |
| SLC46A1-10617Z | Recombinant Zebrafish SLC46A1 | Mammalian Cell | Zebrafish | His |
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| SLC46A1-15460M | Recombinant Mouse SLC46A1 Protein | Mammalian Cell | Mouse | His |
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| SLC46A1-4507C | Recombinant Chicken SLC46A1 | Mammalian Cell | Chicken | His |
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| SLC46A1-5544R | Recombinant Rat SLC46A1 Protein | Mammalian Cell | Rat | His |
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| SLC46A1-0916H | Recombinant Human SLC46A1 Protein (E2-P459), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | E2-P459 |
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| SLC46A1-5203R | Recombinant Rat SLC46A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC46A1-5203R-B | Recombinant Rat SLC46A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC46A1-8382M | Recombinant Mouse SLC46A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC46A1-8382M-B | Recombinant Mouse SLC46A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC46A1 involved in several pathways and played different roles in them. We selected most pathways SLC46A1 participated on our site, such as Iron uptake and transport,Metabolism,Metabolism of folate and pterines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC46A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of water-soluble vitamins and cofactors | SLC25A16,SLC5A6A,SLC25A32,GSTO2,SLC5A6B,CYB5R3,GPHNA,SLC25A32B,CD320,CTRB1 |
| Metabolism of folate and pterines | SLC25A32,SLC25A32A,SLC25A32B |
| Vitamin digestion and absorption | APOA4,GIF,SLC19A3,SLC5A6,LMBRD1,SLC19A2,PNLIP,APOA1,TCN2,SCARB1 |
| Metabolism of vitamins and cofactors | SLC19A2,GPHNA,CYB5R3,CYB5A,SLC5A6B,LOC100686744,CD320,SLC23A2,SLC5A6A,GSTO2 |
| Transmembrane transport of small molecules | SLC4A2B,SLC9B2,SLC12A1,CLCNK,RHCGL1,ANO10A,TRPM6,SLC17A1,ATP2B3A,ABCA8 |
| Mineral absorption | ATP1A3,MT1B,SLC8A1,MT2A,VDR,TRPV6,Trf,MT1H,HMOX2,MT1M |
| Metabolism | ABHD3,MED25,UCP3,SLC35B3,ACOT8,ELA2,MED18,CLPS,CYP2U1,FA2H |
| Iron uptake and transport | ABCG2D,ATP6V1G3,SLC22A17,LCN2,FTH1B,FTH1A,TFA,CP,FLVCR1,MFSD7B |
Protein Function
SLC46A1 has several biochemical functions, for example, folic acid binding,folic acid transporter activity,NOT heme transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC46A1 itself. We selected most functions SLC46A1 had, and list some proteins which have the same functions with SLC46A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen ion transmembrane transporter activity | ATP6V1B2,ATP5I,ATP5L,ATP6V1AA,ATP5G3,ATP5S,ATP6V1C1B,SLC36A2,ATP6V0E2,ATP6V0A1B |
| methotrexate transporter activity | SLC19A1 |
| folic acid transporter activity | FOLR2,FOLR1,DAAM2,SLC25A32,SLC19A1,SLC19A2 |
| folic acid binding | TYMS,DMGDH,FOLR1,GNMT,DAAM2,MTHFS,FOLR3,FTCD,SLC19A1,DHFR |
Interacting Protein
SLC46A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC46A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC46A1.
b3xyc5_sollc
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References
- Gonen, N; Assaraf, YG; et al. The Obligatory Intestinal Folate Transporter PCFT (SLC46A1) Is Regulated by Nuclear Respiratory Factor 1. JOURNAL OF BIOLOGICAL CHEMISTRY 285:33602-33613(2010).
- Laftah, AH; Latunde-Dada, GO; et al. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). BRITISH JOURNAL OF NUTRITION 101:1150-1156(2009).
- Unal, ES; Zhao, RB; et al. N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT). BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1778:1407-1414(2008).
- Qiu, A; Min, SH; et al. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 293:C1669-C1678(2007).
