SLC40A1
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Official Full Name
solute carrier family 40 (iron-regulated transporter), member 1 -
Overview
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008] -
Synonyms
SLC40A1;solute carrier family 40 (iron-regulated transporter), member 1;FPN1;HFE4;MTP1;IREG1;MST079;MSTP079;SLC11A3;solute carrier family 40 member 1;iron regulated gene 1;putative ferroportin 1 variant IIIA;putative ferroportin 1 variant IIIB;solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
Recombinant Proteins
- Mouse
- Chicken
- Human
- Zebrafish
- Mammalian Cell
- E.coli
- E.coli expression system
- Insect Cell
- Wheat Germ
- Protein Conjugation
- Human Spleen
- HEK293
- His
- His&GST
- Non
- His&Flag&MBP
- GST
- His&Fc&Avi
Involved Pathway
SLC40A1 involved in several pathways and played different roles in them. We selected most pathways SLC40A1 participated on our site, such as Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC40A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | S100G,ATP1A1,ATP2B1,ATP1A3,Trf,VDR,TRPV6,ATP1A2,FTH1,SLC31A1 |
Protein Function
SLC40A1 has several biochemical functions, for example, ferrous iron transmembrane transporter activity,iron channel activity,iron ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC40A1 itself. We selected most functions SLC40A1 had, and list some proteins which have the same functions with SLC40A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | VMN1R41,SV2A,GRIA3A,RTN4R,MED16,PVRL1A,CD160,PVRL2L,MED17,FAS |
| protein binding | STK10,PSMB10,POT1,JPH2,PRKD1,NFE2L2,ZC3H11A,AKAP8L,APOOL,BTN2A2 |
| peptide hormone binding | GCGR,AGTR1A,CRHR2,ECE1,GIPR,AGTR1B,NPR2,NPR1,NPR3,PTH1RA |
| iron ion transmembrane transporter activity | TTYH1 |
| ferrous iron transmembrane transporter activity | SLC11A2,SLC39A14 |
Interacting Protein
SLC40A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC40A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC40A1.
APP;CP;APP;Rps27a;ucpA;GOLM1
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References
- Lee, PL; Reid, TJ; et al. Sideroblastic anemia, iron overload, and ALAS2 R452S in African-American males: phenotype and genotype features of five unrelated patients. AMERICAN JOURNAL OF HEMATOLOGY 86:787-789(2011).
- Canonne-Hergaux, F; Donovan, A; et al. Comparative studies of duodenal and macrophage ferroportin proteins. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 290:G156-G163(2006).
