SLC38A1
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Official Full Name
solute carrier family 38, member 1 -
Overview
Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism,;detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the;detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter,;glutamate (Gu et al., 2001 (PubMed 11325958)). -
Synonyms
SLC38A1;solute carrier family 38, member 1;sodium-coupled neutral amino acid transporter 1;ATA1;NAT2;SAT1;Amino acid transporter A1;Amino acid transporter system A1;ATA 1;N-system amino acid transporter 2;NAT 2;S38A1_HUMAN;SAT 1;SNAT 1;SNAT1;Solute carrier family 38 member 1;System A amino acid transporter 1;System N amino acid transporter 1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Human
- Mammalian Cell
- Insect Cell
- HEK293
- His
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC38A1 involved in several pathways and played different roles in them. We selected most pathways SLC38A1 participated on our site, such as Glutamatergic synapse,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC38A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | GABRQ,GABRE,SLC12A5,GNG11,GABRB2,GABRR3,GABARAP,GABRP,GNAI1,GNAI3 |
| Glutamatergic synapse | MAPK3,GRIA3,PRKACA,Adcy4,SLC38A3,PLCB3,GNG12,SLC1A1,DLGAP1,SHANK2 |
Protein Function
SLC38A1 has several biochemical functions, for example, L-glutamine transmembrane transporter activity,symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC38A1 itself. We selected most functions SLC38A1 had, and list some proteins which have the same functions with SLC38A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-glutamine transmembrane transporter activity | SLC38A3,SLC1A5,SLC38A7,SLC1A4 |
| symporter activity | SLC16A11,SLC6A1,SLC17A6B,SLC22A5,SLC17A7,SLC6A1B,SLC1A2A,SLC46A2,SLC6A6A,SLC5A4 |
Interacting Protein
SLC38A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC38A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC38A1.
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References
- Liu, NM; Yokota, T; et al. Transcription Profiles of Endothelial Cells in the Rat Ductus Arteriosus during a Perinatal Period. PLOS ONE 8:-(2013).
- Hagglund, MGA; Sreedharan, S; et al. Identification of SLC38A7 (SNAT7) Protein as a Glutamine Transporter Expressed in Neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 286:20500-20511(2011).
- Solbu, TT; Bjorkmo, M; et al. SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons. FRONTIERS IN NEUROANATOMY 4:-(2010).
- Blot, A; Billups, D; et al. FUNCTIONAL EXPRESSION OF TWO SYSTEM A GLUTAMINE TRANSPORTER ISOFORMS IN RAT AUDITORY BRAINSTEM NEURONS. NEUROSCIENCE 164:998-1008(2009).
