SLC33A1
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Official Full Name
solute carrier family 33 (acetyl-CoA transporter), member 1 -
Overview
The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
SLC33A1;solute carrier family 33 (acetyl-CoA transporter), member 1;ACATN, acetyl Coenzyme A transporter , spastic paraplegia 42 (autosomal dominant) , SPG42;acetyl-coenzyme A transporter 1;AT 1;AT1;ACATN;Acetyl CoA transporter;Acetyl Coenzyme A transporter;Acetyl coenzyme A transporter 1;Human Angiotensin II Type 1 Receptor;Solute carrier family 33 (acetyl CoA transporter) member 1;Solute carrier family 33 member 1;spastic paraplegia 42 (autosomal dominant);SPG42;OTTHUMP00000212981;OTTHUMP00000212982;OTTHUMP00000212983;AT-1
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Rat
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Insect Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC33A1 involved in several pathways and played different roles in them. We selected most pathways SLC33A1 participated on our site, such as Glycosphingolipid biosynthesis - ganglio series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC33A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - ganglio series | ST3GAL2,ST6GALNAC3,ST3GAL5,ST8SIA1,GLB1,B3GALT4,B4GALNT1,ST6GALNAC5,ST6GALNAC6,ST8SIA5 |
| Metabolic pathways | REV3L,P4HA1A,ALG6,HMGCRB,NT5C3L,UCK2B,DHFRL1,LPIN3,ALAS1,COX11 |
Protein Function
SLC33A1 has several biochemical functions, for example, acetyl-CoA transporter activity,solute:proton symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC33A1 itself. We selected most functions SLC33A1 had, and list some proteins which have the same functions with SLC33A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| solute:proton symporter activity | MFSD3,SLC11A2 |
Interacting Protein
SLC33A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC33A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC33A1.
METTL8;MSL1;HAX1;CLIC1;SLC27A2;PHGDH;ZW10;SNUPN;MT-ATP6;MT-ATP8;PFN1;HSP90AB1;HSP90B1;ATP2A2;ATP5A1;EEF1G;CANX;EEF1D;SLC7A1;MAT2A
Resources
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References
- Mao, F; Li, ZH; et al. Identification and Functional Analysis of a SLC33A1: c.339T > G (p.Ser113Arg) Variant in the Original SPG42 Family. HUMAN MUTATION 36:240-249(2015).
- Peng, YJ; Li, M; et al. Deficient Import of Acetyl-CoA into the ER Lumen Causes Neurodegeneration and Propensity to Infections, Inflammation, and Cancer. JOURNAL OF NEUROSCIENCE 34:6772-6789(2014).
