SLC29A4
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Official Full Name
solute carrier family 29 (nucleoside transporters), member 4 -
Overview
This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. -
Synonyms
SLC29A4;solute carrier family 29 (nucleoside transporters), member 4;equilibrative nucleoside transporter 4;ENT4;FLJ34923;Brain transport protein PMAT;ENT 4;Plasma membrane monoamine transporter;PMAT;Solute carrier family 29 (nucleoside transporters) member 4;Solute carrier family 29 member 4;hENT4;OTTHUMP00000025415;OTTHUMP00000200583;OTTHUMP00000200584
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC29A4-3944H | Recombinant Human SLC29A4 protein, His-tagged | E.coli | Human | His | 239-337 aa | |
| SLC29A4-15358M | Recombinant Mouse SLC29A4 Protein | Mammalian Cell | Mouse | His |
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| SLC29A4-5070Z | Recombinant Zebrafish SLC29A4 | Mammalian Cell | Zebrafish | His |
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| SLC29A4-602HCL | Recombinant Human SLC29A4 lysate | HEK293 | Human | Non |
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| SLC29A4-8309M | Recombinant Mouse SLC29A4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC29A4-8309M-B | Recombinant Mouse SLC29A4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC29A4 involved in several pathways and played different roles in them. We selected most pathways SLC29A4 participated on our site, such as SLC-mediated transmembrane transport,Transmembrane transport of small molecules,Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC29A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | ATP1A1A.4,SLC43A2B,SLC6A1B,TFR1B,SLC43A2A,SLC39A3,SLC5A4,SLC7A6,CCC2,SLC6A20 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane | SLC29A3,SLC29A2,SLC28A2,SLC28A1,SLC28A3,SLC29A1A |
| Transport of vitamins, nucleosides, and related molecules | SLC28A2,SLCO2B1,SLCO4A1,SLC29A1A,SLC29A3,SLCO3A1,SLCO4C1,SLC5A6B,SLCO2A1,SLC29A2 |
| SLC-mediated transmembrane transport | SLC35A3B,SLC7A3,SLC27A4,SLC28A1,SLCO1B1,SLC6A1A,SLC6A6A,RHBG,SLC26A3.1,SLC1A3A |
Protein Function
SLC29A4 has several biochemical functions, for example, monoamine transmembrane transporter activity,nucleoside transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC29A4 itself. We selected most functions SLC29A4 had, and list some proteins which have the same functions with SLC29A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleoside transmembrane transporter activity | SLC29A1,SLC28A1,SLC29A3,SLC29A2,SLC29A1A |
| monoamine transmembrane transporter activity | SLC22A1,SLC18A1,SLC6A2,SLC6A4,SLC18A2,SLC6A3 |
Interacting Protein
SLC29A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC29A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC29A4.
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References
- Adamsen, D; Ramaekers, V; et al. Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. MOLECULAR AUTISM 5:-(2014).
- Duan, HC; Wang, JN; et al. Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4)gene. FASEB JOURNAL 27:-(2013).
