SLC29A1
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Official Full Name
solute carrier family 29 (equilibrative nucleoside transporter), member 1 -
Overview
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
SLC29A1;solute carrier family 29 (equilibrative nucleoside transporter), member 1;ENT1;equilibrative nucleoside transporter 1;nucleoside transporter, es-type;solute carrier family 29 member 1;solute carrier family 29, member 1;equilibrative NBMPR-sensitive nucleoside transporter;solute carrier family 29 (nucleoside transporters), member 1;equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- Insect Cell
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Flag&MBP
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
SLC29A1 involved in several pathways and played different roles in them. We selected most pathways SLC29A1 participated on our site, such as Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC29A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | GRIN2A,CREB3L2,NPY,CALM2,HIST2H2AA4,CALML3,HIST1H2AL,HIST3H2BB,HDAC3,TH |
Protein Function
SLC29A1 has several biochemical functions, for example, nucleoside transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC29A1 itself. We selected most functions SLC29A1 had, and list some proteins which have the same functions with SLC29A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleoside transmembrane transporter activity | SLC28A1,SLC29A2,SLC29A1A,SLC29A3,SLC29A4 |
Interacting Protein
SLC29A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC29A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC29A1.
CREB3;STK19;b3xyc5_sollc
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