SLC27A5
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Official Full Name
solute carrier family 27 (fatty acid transporter), member 5 -
Overview
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. -
Synonyms
SLC27A5;solute carrier family 27 (fatty acid transporter), member 5;bile acyl-CoA synthetase;ACSB;ACSVL6;FACVL3;FATP5;fatty acid Coenzyme A ligase;very long chain 3;FLJ22987;VLACSR;VLCS H2;VLCSH2;BA CoA ligase;BACS;BAL;Bile acid CoA ligase;Bile acyl CoA synthetase;Cholate CoA ligase;FATP 5;Fatty acid Coenzyme A ligase very long chain 3;Fatty acid transport protein 5;Solute carrier family 27 (fatty acid transporter) member 5;Solute carrier family 27 member 5;Very long chain acyl CoA synthetase homolog 2;Very long chain acyl CoA synthetase related protein;VLACS related;FATP-5;BA-CoA ligase;VLACS-related;cholate--CoA ligase;bile acid-CoA ligase;very long-chain acyl-CoA synthetase homolog 2;fatty-acid-Coenzyme A ligase, very long-chain 3;very long-chain acyl-CoA synthetase-related protein;VLCS-H2
Recombinant Proteins
- Mouse
- Rat
- Human
- Mus musculus
- E.coli
- Mammalian Cell
- E.coli expression system
- HEK293
- His
- His&GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Slc27a5-1770M | Recombinant Mouse Slc27a5 protein, His-tagged | E.coli | Mouse | His | Glu471~Leu689 |
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| Slc27a5-1771M | Recombinant Mouse Slc27a5 protein, His & GST-tagged | E.coli | Mouse | His&GST | Glu471~Leu689 |
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| Slc27a5-1772R | Recombinant Rat Slc27a5 protein, His & GST-tagged | E.coli | Rat | His&GST | Glu488~Leu690 |
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| SLC27A5-5488R | Recombinant Rat SLC27A5 Protein | Mammalian Cell | Rat | His |
|
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| SLC27A5-1626HCL | Recombinant Human SLC27A5 cell lysate | Human | Non |
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| RFL23529RF | Recombinant Full Length Rat Bile Acyl-Coa Synthetase(Slc27A5) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-690) |
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| RFL5439MF | Recombinant Full Length Mouse Bile Acyl-Coa Synthetase(Slc27A5) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-689) |
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| SLC27A5-5147R | Recombinant Rat SLC27A5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC27A5-5147R-B | Recombinant Rat SLC27A5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SLC27A5 involved in several pathways and played different roles in them. We selected most pathways SLC27A5 participated on our site, such as Bile acid and bile salt metabolism,Bile secretion,Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC27A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | FBP1B,CYP2C55,DHRS13L1,EXT2,ABO,GPAM,CYP2R1,POLR1A,PIP5K1BB,SDHC |
| Metabolism of lipids and lipoproteins | AKR1C6,APOEA,ARSF,G0S2,FABP12,ARSJ,APOEB,BRSK2,DECR1,ACOT7 |
| PPAR signaling pathway | RXRGB,APOA1A,ACSL4,APOA5,APOA2,CYP4A14,PDPK1,CYP4A12A,FABP7B,ACOX2 |
| Primary bile acid biosynthesis | CYP46A1.4,SCP2,CYP8B1,BAAT,CH25HL2,CYP46A1.3,AMACR,CYP7B1,CYP7A1A,HSD17B4 |
| Bile secretion | ATP1B2,SULT2A1,SLCO1A4,ABCB1A,SLC4A4,SLCO1B2,SLC51B,ABCB1,HMGCR,OSTA |
| Metabolism | SLC25A15A,GCHFR,DPYDA.1,NAMPT,SLC19A2,PPARGC1B,UCP3,SPTLC1,ACOT11A,GLTP |
| Bile acid and bile salt metabolism | CYP46A1,Alb,AKR1C2,CYP8B2,AKR1C21,AKR1C6,SLC27A2,SLCO1B1,SLC27A2A,CYP27A1 |
| Insulin resistance | NR1H2,PDPK1,PRKAG3B,PIK3R5,PTPN1,PRKAG2A,IKBKB,NFKB1,PRKAB1A,SLC2A1 |
Protein Function
SLC27A5 has several biochemical functions, for example, ATP binding,cholate-CoA ligase activity,fatty acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC27A5 itself. We selected most functions SLC27A5 had, and list some proteins which have the same functions with SLC27A5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ITPKB,PRKG2,AKT2,FARS2,UBE2L3B,UBE2U,YSK4,PDPK1,ACTR1,DHX36 |
| protein complex binding | TULP2,NOG,ARRB2,YWHAB,MYC,RXRA,AKAP5,PTPRF,CTSL2,ANKRD32 |
| long-chain fatty acid-CoA ligase activity | ACSL1,SLC27A3,ACSBG2,SLC27A1B,SLC27A1A,SLC27A4,ACSL5,ACSL3,ACSL4,ACSBG1 |
| fatty acid transporter activity | SLC27A4,SLC27A2,SLC27A1A,SLC27A1B |
| very long-chain fatty acid-CoA ligase activity | SLC27A2,ACSL4,SLC27A1B,SLC27A4,SLC27A1A,SLC27A3,ACSBG1 |
Interacting Protein
SLC27A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC27A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC27A5.
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References
- Hadzic, N; Bull, LN; et al. Diagnosis in bile acid-CoA: Amino acid N-acyltransferase deficiency. WORLD JOURNAL OF GASTROENTEROLOGY 18:3322-3326(2012).
