SLC27A4
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Official Full Name
solute carrier family 27 (fatty acid transporter), member 4 -
Overview
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010] -
Synonyms
SLC27A4;solute carrier family 27 (fatty acid transporter), member 4;IPS;FATP4;ACSVL4;long-chain fatty acid transport protein 4
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Mus musculus
- Macaca fascicularis
- Pongo Abelii
- E.coli
- Mammalian Cell
- Human Cell
- E.coli expression system
- Insect Cell
- HEK293
- GST
- His
- Non
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC27A4 involved in several pathways and played different roles in them. We selected most pathways SLC27A4 participated on our site, such as Fat digestion and absorption,Insulin resistance,PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC27A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | SCP2A,APOA2,SCD,ACAA1,CYP7A1A,FABP7,SCD5,ACSBG1,ACSL3B,UCP1 |
| Transmembrane transport of small molecules | CLCN4,SLC4A3,SLC35B4,SLC14A1,CLCN1,SLC3A2A,ATP1A1A.4,SLC1A2B,CP,TRDN |
| Insulin resistance | CREB3L3,PRKAG3B,PYGM,SLC2A2,PRKAA1,PPP1R3B,PRKCBA,PPP1R3CB,SLC27A3,PRKAA2 |
| Fat digestion and absorption | SCARB1,APOA4,PLA2G12B,PPAP2A,ABCA1,Cel,PNLIPRP2,MTTP,PLA2G2F,PPAP2C |
| SLC-mediated transmembrane transport | SLC39A6,SLC9A7,SLC17A7A,SLC6A1B,SLC13A1,SLC2A10,SLC5A6B,SLC2A15B,SLC24A4A,SLC6A9 |
| Transport of vitamins, nucleosides, and related molecules | SLC35A2,SLC29A2,SLC35A3A,SLC29A3,SLC35A3B,SLC28A3,SLCO3A1,SLC35A3,LCN9,SLC28A1 |
| Transport of fatty acids | LCN1,LCN15,LCN12,APOD,LCN9 |
Protein Function
SLC27A4 has several biochemical functions, for example, fatty acid transporter activity,long-chain fatty acid-CoA ligase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC27A4 itself. We selected most functions SLC27A4 had, and list some proteins which have the same functions with SLC27A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fatty acid transporter activity | SLC27A2,SLC27A1B,SLC27A5,SLC27A1A |
| very long-chain fatty acid-CoA ligase activity | SLC27A2,ACSBG1,SLC27A3,ACSL4,SLC27A5,SLC27A1A,SLC27A1B |
| long-chain fatty acid-CoA ligase activity | SLC27A2,ACSL4,ACSL5,ACSL3,SLC27A3,ACSL1,ACSBG1,SLC27A1B,ACSBG2,SLC27A5 |
| nucleotide binding | ADCY2B,HSP70,RHOAE,UBE2IA,PPRC1,HNRNPABB,CDK14,CSNK1DB,SRPK1B,POLA1 |
Interacting Protein
SLC27A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC27A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC27A4.
BECN1;NIPAL4;TMBIM4;EPS8;Tpx2;E2F3;vpu;Sod1;PCNA;Dennd6a;Strn3
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