SLC23A1
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Official Full Name
solute carrier family 23 (nucleobase transporters), member 1 -
Overview
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC23A1;solute carrier family 23 (nucleobase transporters), member 1;SLC23A2, solute carrier family 23 (nucleobase transporters), member 2;solute carrier family 23 member 1;SVCT1;YSPL3;hSVCT1;Na(+)/L-ascorbic acid transporter 1;S23A1_HUMAN;Sodium-dependent vitamin C transporter 1;Yolk sac permease-like molecule 3;sodium-dependent vitamin C transporter-1;solute carrier family 23 (nucleobase transporters), member 2;SLC23A2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
Involved Pathway
SLC23A1 involved in several pathways and played different roles in them. We selected most pathways SLC23A1 participated on our site, such as Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC23A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | GIF,LMBRD1,MMACHC,SLC19A1,SLC19A3,PNLIP,SCARB1,APOA1,TCN2,SLC46A1 |
Protein Function
SLC23A1 has several biochemical functions, for example, L-ascorbate:sodium symporter activity,L-ascorbic acid transporter activity,dehydroascorbic acid transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC23A1 itself. We selected most functions SLC23A1 had, and list some proteins which have the same functions with SLC23A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium ion transmembrane transporter activity | SLC12A1,SLC12A10.3,SLC12A10.1,ASIC4,CNNM4,SLC12A10.2,TRAPPC10,SLC12A3 |
| L-ascorbate:sodium symporter activity | SLC23A2 |
| sodium-dependent L-ascorbate transmembrane transporter activity | SLC23A2 |
| transporter activity | RLBP1A,SLCO1A4,MIPB,AQP1A.2,PTGDSA,AQP1A.1,SEC22A,TMEM184A,CHP,APODB |
| symporter activity | SLC17A6A,SLC6A13L,SLC6A13,SLC1A8B,SLC22A18,SLC6A18,SLC16A14,SLC38A2,SLC16A6,MFSD2AA |
| dehydroascorbic acid transporter activity | SLC2A2,SLC2A1 |
| L-ascorbic acid transporter activity | SLC23A2 |
Interacting Protein
SLC23A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC23A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC23A1.
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References
- Wade, KH; Forouhi, NG; et al. Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. AMERICAN JOURNAL OF CLINICAL NUTRITION 101:202-209(2015).
- Senthilkumari, S; Talwar, B; et al. Polymorphisms in sodium-dependent vitamin C transporter genes and plasma, aqueous humor and lens nucleus ascorbate concentrations in an ascorbate depleted setting. EXPERIMENTAL EYE RESEARCH 124:24-30(2014).
