SLC22A6
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Official Full Name
solute carrier family 22 (organic anion transporter), member 6 -
Overview
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. -
Synonyms
SLC22A6;solute carrier family 22 (organic anion transporter), member 6;solute carrier family 22 member 6;OAT1;PAHT;ROAT1;hPAHT;hROAT1;PAH transporter;organic anion transporter 1;para-aminohippurate transporter;renal organic anion transporter 1
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mammalian Cell
- E.coli
- HEK293
- Insect Cell
- His
- GST
- Non
- His&Flag&Strep
- His&Flag&MBP
- His&Fc&Avi
Involved Pathway
SLC22A6 involved in several pathways and played different roles in them. We selected most pathways SLC22A6 participated on our site, such as Organic anion transport,Organic cation/anion/zwitterion transport,SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transmembrane transport of small molecules | SLC39A2,ANKHA,ABCG4B,AQP8A.1,FKBP1B,SLC20A1B,CTNS,SLC9A6A,TTYH3,TRPM1A |
| SLC-mediated transmembrane transport | SLC22A7,SLC27A4,SLC2A15A,SLC43A1B,SLC1A7A,SLC26A3.1,SLC30A2,SLC26A6L,SLC26A3.2,SLC39A7 |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC2A15B,SLC6A15,SLC6A2,SLC39A1,SLC31A1,RHCGA,SLC6A19B,SLC2A10,SLC30A1A,SLC30A1B |
| Organic anion transport | SLC22A7A,SLC22A12,SLC22A7,SLC22A7B.1 |
| Organic cation/anion/zwitterion transport | SLC22A18,SLC22A7,SLC22A7A,SLC22A15,SLC22A7B.1,SLC22A16,SLC22A12 |
Protein Function
SLC22A6 has several biochemical functions, for example, chloride ion binding,inorganic anion exchanger activity,organic anion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A6 itself. We selected most functions SLC22A6 had, and list some proteins which have the same functions with SLC22A6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chloride ion binding | Amy1,ACE,CTSC,NLGN4X,AMY2A |
| protein homodimerization activity | LRP4,CHMP4B,SQSTM1,NPPC,LRRK2,NKX2,CEACAM1,XPA,CBX5,HLA-G |
| inorganic anion exchanger activity | SLC4A8,SLC22A12,SLC4A2B,SLC22A8,SLC22A9,SLC4A3,SLC4A1,SLC4A1B,SLC4A11,Slc4a2 |
| protein binding | SLC3A1,YBX1,ZFP259,S100A12,SEMA6A,GBA,FAM58A,ITGAV,FRMD7,CCDC42 |
| sodium-independent organic anion transmembrane transporter activity | SLCO1F1,SLC22A24,SLCO4C1,SLC22A12,SLCO2A1,SLCO4A1,SLC22A8,SLCO2B1,SLC22A9,SLCO1F4 |
| organic anion transmembrane transporter activity | SLC22A23,ABCC3,ABCC11,SLC22A31,SLC22A20,SLCO1A5,SLCO4C1,SLCO1A2,SLC22A7B.1,SLCO1B3 |
Interacting Protein
SLC22A6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A6.
APPBP2
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References
- Breljak, D; Brzica, H; et al. Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 304:F1114-F1126(2013).
