SLC22A18
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Official Full Name
solute carrier family 22, member 18 -
Overview
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. -
Synonyms
SLC22A18;solute carrier family 22, member 18;BWSCR1A, IMPT1, ORCTL2, SLC22A1L, solute carrier family 22 (organic cation transporter), member 1 like;solute carrier family 22 member 18;BWR1A;ITM;TSSC5;IMPT1;OTTMUSP00000030800;Beckwith Wiedemann syndrome chromosomal region 1 candidate gene A protein;BWSCR1A;DKFZp667A184;Efflux transporter like protein;HET;Imprinted multi membrane spanning polyspecific transporter related protein 1;MGC94186;ORCTL 2;ORCTL2;Organic cation transporter like protein 2;OTTMUSP00000030799;p45 Beckwith Wiedemann region 1 A;p45 BWR1A;SLC22A1L;Solute carrier family 22 member 1 like;TSSC5v;Tumor suppressing STF cDNA 5 protein;Tumor suppressing subchromosomal transferable fragment candidate gene 5 protein;ORCTL-2;OTTHUMP00000011731;OTTHUMP00000011732;OTTHUMP00000011733;OTTHUMP00000012598;efflux transporter-like protein;p45 Beckwith-Wiedemann region 1A;organic cation transporter-like 2;p45-Beckwith-Wiedemann region 1 A;tumor-suppressing STF cDNA 5 protein;organic cation transporter-like protein 2;Beckwith-Wiedemann syndrome chromosome region 1, candidate A;beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein;imprinted multi-membrane spanning polyspecific transporter-related protein 1;imprinted multi-membrane-spanning polyspecific transporter-related protein 1;tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein;p45-BWR1A
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Flag&MBP
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SLC22A18 involved in several pathways and played different roles in them. We selected most pathways SLC22A18 participated on our site, such as Organic cation transport,Organic cation/anion/zwitterion transport,SLC-mediated transmembrane transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC22A18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | SLC2A10,SLC22A15,SLC6A20A,RHCGB,SLC30A5,RHAG,SLC6A6,SLC30A6,SLC14A1,SLC39A6 |
| Transmembrane transport of small molecules | CLCNKA,SLC15A1B,SLC4A8,FXYD6-FXYD2,SLC39A10,SLCO2A1,SLC44A5B,TFR1B,SLC2A10,ABCG4B |
| Organic cation/anion/zwitterion transport | SLC22A6,SLC22A12,SLC22A15,SLC22A7,SLC22A7A,SLC22A16,SLC22A7B.1 |
| SLC-mediated transmembrane transport | RHCGA,SLC6A7,SLC5A9,SLC20A1A,SLC26A3.2,SLC6A6,SLC13A4,SLC2A10,SLC30A3,SLC30A1B |
| Organic cation transport | SLC22A15,SLC22A16 |
Protein Function
SLC22A18 has several biochemical functions, for example, drug transmembrane transporter activity,symporter activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC22A18 itself. We selected most functions SLC22A18 had, and list some proteins which have the same functions with SLC22A18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug transmembrane transporter activity | SLC18A3B,SLC17A3,SLCO1B2,SLC47A1,Abcb1b,EBP,SLC18A1,SLC18A3A,SLC22A5,SLC47A2 |
| ubiquitin protein ligase binding | UBE2NA,CBS,MOAP1,ACVR1B,TP53,UBE2A,TRIB3,TRAF3,BECN1,SPOP |
| symporter activity | SLC6A19A,SLC5A11,SLC15A5,SLC17A8,MFSD2A,SLC6A6B,SLC6A4A,SLC10A7,SLC17A6A,SLC16A11 |
Interacting Protein
SLC22A18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC22A18 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC22A18.
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References
- Zhang, BC; Liu, T; et al. microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 74:111-118(2015).
- Chu, SH; Zhou, ZM; et al. In vitro and in vivo radiosensitization of human glioma U251 cells induced by upregulated expression of SLC22A18. CANCER GENE THERAPY 21:103-109(2014).
