SLC16A2
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Official Full Name
solute carrier family 16, member 2 (thyroid hormone transporter) -
Overview
This gene encodes an integral membrane protein transporter of thyroid hormone; specifically, cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues including brain, heart, placenta, lung, kidney, skeletal muscle, and liver. This gene likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. -
Synonyms
SLC16A2;solute carrier family 16, member 2 (thyroid hormone transporter);AHDS, Allan Herndon Dudley syndrome , DXS128, mental retardation, X linked 22 , MRX22, solute carrier family 16 (monocarboxylic acid transporters), member 2 , solute carrier fa
Recombinant Proteins
- Mouse
- Rat
- Zebrafish
- Human
- Mammalian Cell
- Insect Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- His&Flag&MBP
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC16A2-15233M | Recombinant Mouse SLC16A2 Protein | Mammalian Cell | Mouse | His |
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| SLC16A2-5440R | Recombinant Rat SLC16A2 Protein | Mammalian Cell | Rat | His |
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| SLC16A2-8222Z | Recombinant Zebrafish SLC16A2 | Mammalian Cell | Zebrafish | His |
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| SLC16A2-1345S | Recombinant Human SLC16A2 Protein (M1-I539), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | M1-I539 |
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| SLC16A2-1346S | Recombinant Human SLC16A2 Protein (A2-I539), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | A2-I539 |
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| SLC16A2-3340H | Recombinant Human SLC16A2 Protein | Wheat Germ | Human | Non |
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| SLC16A2-5099R | Recombinant Rat SLC16A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLC16A2-5099R-B | Recombinant Rat SLC16A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLC16A2-6784HF | Recombinant Full Length Human SLC16A2 Protein | In Vitro Cell Free System | Human | Full L. 461 amino acids |
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| SLC16A2-6790HF | Recombinant Full Length Human SLC16A2 Protein | In Vitro Cell Free System | Human | Full L. 1033 amino acids |
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| SLC16A2-8233M | Recombinant Mouse SLC16A2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC16A2-8233M-B | Recombinant Mouse SLC16A2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| SLC16A2-87H | Recombinant Human SLC16A2 Protein | Wheat Germ | Human | Non |
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Involved Pathway
SLC16A2 involved in several pathways and played different roles in them. We selected most pathways SLC16A2 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC16A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone signaling pathway | PLCE1,ATP1A2,BMP4,CASP9,DIO1,ITGAV,TBC1D4,TP53,PFKP,ATP1B2 |
Protein Function
SLC16A2 has several biochemical functions, for example, symporter activity,thyroid hormone transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC16A2 itself. We selected most functions SLC16A2 had, and list some proteins which have the same functions with SLC16A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| symporter activity | SLC1A8B,SLC23A1,SLC24A1,SLC17A6A,SLC10A5,SLC16A6,SLC5A4,SLC6A6B,SLC6A1A,SLC5A8 |
| thyroid hormone transmembrane transporter activity | SLCO4A1,SLCO1A5,SLCO1C1,SLC16A10 |
Interacting Protein
SLC16A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC16A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC16A2.
Resources
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References
- Merezhinskaya, N; Fishbein, WN; et al. Monocarboxylate transporters: Past, present, and future. HISTOLOGY AND HISTOPATHOLOGY 24:243-264(2009).
- Moeller, LC; Dumitrescu, AM; et al. Thyroid hormone responsive genes in cultured human fibroblasts. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 90:936-943(2005).
- Capri, Y; Friesema, ECH; et al. Relevance of Different Cellular Models in Determining the Effects of Mutations on SLC16A2/MCT8 Thyroid Hormone Transporter Function and Genotype-Phenotype Correlation. HUMAN MUTATION 34:1018-1025(2013).
