SLC12A3

  • Official Full Name

    solute carrier family 12 (sodium/chloride transporters), member 3

  • Overview

    This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartters syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    SLC12A3;solute carrier family 12 (sodium/chloride transporters), member 3;solute carrier family 12 member 3;NCCT;Na-Cl symporter;thiazide-sensitive Na-Cl cotransporter;thiazide-sensitive sodium-chloride cotransporter;NaCl electroneutral thiazide-se

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Mammalian cells
  • HEK293
  • HEK293T
  • His
  • Flag
  • His&Fc&Avi
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC12A3-1203H Recombinant Human SLC12A3 protein, His-tagged E.coli Human His Glu3~Cys146
SLC12A3-15209M Recombinant Mouse SLC12A3 Protein Mammalian Cell Mouse His
SLC12A3-4132Z Recombinant Zebrafish SLC12A3 Mammalian Cell Zebrafish His
SLC12A3-1562HFL Recombinant Full Length Human SLC12A3 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
SLC12A3-2020H Recombinant Human SLC12A3 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
SLC12A3-2020H-B Recombinant Human SLC12A3 Protein Pre-coupled Magnetic Beads HEK293 Human
Slc12a3-5903M Recombinant Mouse Slc12a3 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
SLC12A3-6672H Recombinant Human SLC12A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
SLC12A3-8217M Recombinant Mouse SLC12A3 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SLC12A3-8217M-B Recombinant Mouse SLC12A3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SLC12A3 involved in several pathways and played different roles in them. We selected most pathways SLC12A3 participated on our site, such as Cation-coupled Chloride cotransporters,SLC-mediated transmembrane transport,Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transmembrane transport of small molecules ADD2,MCOLN2,MIP,TRPM1B,BEST1,CLCN4-2,SLC35B3,GABRR2A,SLC5A6B,SLC12A7
    Transport of inorganic cations/anions and amino acids/oligopeptides SLC9A7,SLC9A8,SLC7A3,SLC1A7B,SLC4A2B,SLC43A2,SLC38A3A,SLC24A6,SLC24A4A,SLC26A6L
    SLC-mediated transmembrane transport SLC4A3,SLCO3A1,SLC26A3,MATE4,SLC44A5B,SLC1A3B,SLC38A4,SLC35B4,SLC6A20,SLC39A1
    Cation-coupled Chloride cotransporters SLC12A1,SLC12A7,SLC12A5B,SLC12A4

    Protein Function

    SLC12A3 has several biochemical functions, for example, cation:chloride symporter activity,enzyme binding,sodium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A3 itself. We selected most functions SLC12A3 had, and list some proteins which have the same functions with SLC12A3. You can find most of the proteins on our site.

    Function Related Protein
    sodium ion transmembrane transporter activity SLC12A1,SLC12A10.1,ASIC4,SLC12A10.2,CNNM4,SLC12A10.3,SLC23A1,TRAPPC10
    enzyme binding PARP4,SNRPD3,AXIN1,CBS,CLSTN2,Txn1,EIF2AK3,DYM,HIST1H2AK,PPP3CA
    sodium:chloride symporter activity SLC12A10.1,SLC12A1,SLC12A10.3,SLC12A10.2
    transporter activity SLC6A20B,SLC2A15A,LCN12,SLC25A31,CRABP1A,SLC23A3,SLC12A10.1,MUP17,SLCO1A6,SLC22A13
    cation:chloride symporter activity SLC12A10.3,SLC12A2,SLC12A10.1,SLC12A5B,SLC12A10.2
    symporter activity SLC6A18,SLC16A9,SLC1A3B,SLC22A5,SLC1A2B,SLC6A11,SLC5A4,SLC17A4,SLC4A11,SLC22A18

    Interacting Protein

    SLC12A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A3.

    Ywhaz

    Resources

    Research Area

    Renal Markers
    Glial Lineage Markers

    References

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