SLC12A2
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Official Full Name
solute carrier family 12 (sodium/potassium/chloride transporters), member 2 -
Overview
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a;membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated;in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
SLC12A2;solute carrier family 12 (sodium/potassium/chloride transporters), member 2;solute carrier family 12 member 2;basolateral Na K Cl symporter;BSC;BSC2;bumetanide sensitive sodium (potassium) chloride cotransporter 1;NKCC1;basolateral Na-K-Cl
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- GST
- His
- His&Flag&MBP
- His&Flag&Strep
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC12A2-3637H | Recombinant Human SLC12A2 protein, GST-tagged | E.coli | Human | GST | 1-280 aa | |
| SLC12A2-3915H | Recombinant Human SLC12A2 protein, His-tagged | E.coli | Human | His | 1-280 aa | |
| SLC12A2-312Z | Recombinant Zebrafish SLC12A2 | Mammalian Cell | Zebrafish | His |
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| SLC12A2-4219R | Recombinant Rhesus monkey SLC12A2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLC12A2-7555Z | Recombinant Zebrafish SLC12A2 | Mammalian Cell | Zebrafish | His |
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| SLC12A2-0290H | Recombinant Human SLC12A2 Protein (E2-S1212), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | E2-S1212 |
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| SLC12A2-0291H | Recombinant Human SLC12A2 Protein (E2-S1212), 8×His-Strep, Flag tagged | Insect Cell | Human | His&Flag&Strep | E2-S1212 |
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| SLC12A2-4035R | Recombinant Rhesus Macaque SLC12A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC12A2-4035R-B | Recombinant Rhesus Macaque SLC12A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SLC12A2 involved in several pathways and played different roles in them. We selected most pathways SLC12A2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC12A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SLC12A2 has several biochemical functions, for example, cation:chloride symporter activity,potassium ion symporter activity,potassium:chloride symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC12A2 itself. We selected most functions SLC12A2 had, and list some proteins which have the same functions with SLC12A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cation:chloride symporter activity | SLC12A10.1,SLC12A3,SLC12A10.3,SLC12A5B,SLC12A10.2 |
| transporter activity | RBP2,PBSN,AP3B2,ATP5G1,FABP12,SLCO1F4,SLC15A4,TCIRG1,ABCA3,TTPAL |
| potassium:chloride symporter activity | SLC12A5B,SLC12A10.1,SLC12A1,SLC12A4,SLC12A5,SLC12A10.2,SLC12A10.3,SLC12A7,SLC12A8 |
| potassium ion symporter activity | SLC12A5B,SLC12A4,SLC12A10.2,SLC12A10.3,SLC12A1,SLC12A10.1,SLC12A8,SLC12A5,SLC12A7 |
Interacting Protein
SLC12A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC12A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC12A2.
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References
- Robel, S; Buckingham, SC; et al. Reactive Astrogliosis Causes the Development of Spontaneous Seizures. JOURNAL OF NEUROSCIENCE 35:3330-3345(2015).
- Liu, Y; Chu, HQ; et al. Age-related change in the expression of NKCC1 in the cochlear lateral wall of C57BL/6J mice. ACTA OTO-LARYNGOLOGICA 134:1047-1051(2014).
