SLC11A2
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Official Full Name
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 -
Overview
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC11A2;solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2;NRAMP2;natural resistance-associated macrophage protein 2;DCT1;DMT1;DMT-1;NRAMP 2;divalent cation transporter 1;FLJ37416
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- Insect Cell
- HEK293
- GST
- His
- His&Flag&MBP
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLC11A2-2696H | Recombinant Human SLC11A2, GST-tagged | E.coli | Human | GST | 1-80aa | |
| SLC11A2-152H | Recombinant Human SLC11A2 protein, His-tagged | E.coli | Human | His | 1-80 aa | |
| SLC11A2-15206M | Recombinant Mouse SLC11A2 Protein | Mammalian Cell | Mouse | His |
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| SLC11A2-3791Z | Recombinant Zebrafish SLC11A2 | Mammalian Cell | Zebrafish | His |
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| SLC11A2-3846C | Recombinant Chicken SLC11A2 | Mammalian Cell | Chicken | His |
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| SLC11A2-3847C | Recombinant Chicken SLC11A2 | Mammalian Cell | Chicken | His |
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| SLC11A2-4218R | Recombinant Rhesus monkey SLC11A2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLC11A2-0560H | Recombinant Human SLC11A2 Protein (V2-R568), 8×His-MBP, Flag tagged | Insect Cell | Human | His&Flag&MBP | V2-R568 |
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| SLC11A2-4034R | Recombinant Rhesus Macaque SLC11A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLC11A2-4034R-B | Recombinant Rhesus Macaque SLC11A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SLC11A2-8215M | Recombinant Mouse SLC11A2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SLC11A2-8215M-B | Recombinant Mouse SLC11A2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SLC11A2 involved in several pathways and played different roles in them. We selected most pathways SLC11A2 participated on our site, such as Lysosome,Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | SLC11A1,CD63,PPT1,MAN2B1,GGA3,ASAH1,ARSG,CTSC,CTSO,ARSB |
| Mineral absorption | ATP7A,ATP1A4,SLC26A6,MT1M,MT2A,MT1E,MT1,MT2,SLC11A1,MT1X |
Protein Function
SLC11A2 has several biochemical functions, for example, cadmium ion binding,cadmium ion transmembrane transporter activity,NOT calcium ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC11A2 itself. We selected most functions SLC11A2 had, and list some proteins which have the same functions with SLC11A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PPM1F,INPP5D,USH2A,OSTC,CST5,TRIM10,BUB1B,POLG,SLC6A20B,MAP4K1 |
| nickel cation binding | CAR3,P2RX2,CA3 |
| copper ion transmembrane transporter activity | ATP7A,MMGT2,SLC31A1,SLC31A2,ATOX1 |
| zinc ion binding | YAF2,MYT1,DBF4B,TRIM35-35,ASTL,PIAS4B,MATR3,TRIM22,XRN2,KDM5BB |
| cobalt ion transmembrane transporter activity | MMGT2 |
| copper ion binding | S100U,LOX,MOXD1L,ANG,METTL17,ATP7B,TRP53,TYRP1,SOD1,LOXL2 |
| zinc ion transmembrane transporter activity | SLC30A8,SLC39A14,SLC30A5,SLC39A11,SLC39A12,SLC30A1,SLC30A2,SLC39A3,SLC39A6,SLC39A2 |
| solute:proton symporter activity | SLC33A1,MFSD3 |
| cobalt ion binding | PML,BIRC5,P2RX2,NUDT16 |
Interacting Protein
SLC11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC11A2.
MT-CO2;b3xyc5_sollc
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References
- Latunde-Dada, GO; Pereira, DIA; et al. A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body Iron. JOURNAL OF NUTRITION 144:1896-1902(2014).
- Garrick, MD; Kuo, HC; et al. Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion. BIOCHEMICAL JOURNAL 398:539-546(2006).
