SLC10A1
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Official Full Name
solute carrier family 10 (sodium/bile acid cotransporter family), member 1 -
Overview
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. -
Synonyms
SLC10A1;solute carrier family 10 (sodium/bile acid cotransporter family), member 1;sodium/bile acid cotransporter;NTCP;growth-inhibiting protein 29;Na(+)/bile acid cotransporter;sodium/taurocholate cotransporter;solute carrier family 10 member 1;N
Recombinant Proteins
- Rat
- Cynomolgus
- Human
- Mus musculus
- Mouse
- Mammalian Cell
- HEK293
- E.coli expression system
- Mammalian cell
- E.coli
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&StrepII&EGFP
- His&Fc&Avi
- His&GST
- Flag
- Myc&DDK
Involved Pathway
SLC10A1 involved in several pathways and played different roles in them. We selected most pathways SLC10A1 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC10A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | AQP1,SLC22A1,NR0B2,SLC22A7,RXRA,ADCY8,SLCO1A4,GNAS,ADCY6,SLCO1B2 |
Protein Function
SLC10A1 has several biochemical functions, for example, bile acid:sodium symporter activity,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC10A1 itself. We selected most functions SLC10A1 had, and list some proteins which have the same functions with SLC10A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| virus receptor activity | HSPA1B,IDE,ITGA2,ITGB7,HSPA1A,PVR,LDLR,EFNB3,HLA-DRB1,GYPA |
| bile acid:sodium symporter activity | SLC10A3,SLC10A2,SLC10A4,SLC10A6 |
Interacting Protein
SLC10A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC10A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC10A1.
C11orf74
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References
- Geyer, J; Fernandes, CF; et al. Cloning and molecular characterization of the orphan carrier protein Slc10a4: Expression in cholinergic neurons of the rat central nervous system. NEUROSCIENCE 152:990-1005(2008).
