SLBP

  • Official Full Name

    stem-loop binding protein

  • Overview

    The SLPB gene (stem-loop binding protein) encodes a protein that binds to the stem-loop structure of replication-dependent histone pre-mRNAs. Histone mRNA lack a polyadenylation signal. Consequently, the interaction of this protein with histone pre-mRNA contributes to efficient 3' end processing by stabilizing the complex between the pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP). Expression of this protein is regulated during the cell cycle,Increasing more than 10-fold during the latter part of G1.

  • Synonyms

    SLBP;stem-loop binding protein;stem loop (histone) binding protein;histone RNA hairpin-binding protein;HBP;histone binding protein;hairpin binding protein, histone;histone stem-loop binding protein;histone stem-loop-binding protein;stem-loop (histone) binding protein

Recombinant Proteins

  • Chicken
  • Mouse
  • Human
  • Zebrafish
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLBP-1221C Recombinant Chicken SLBP Mammalian Cell Chicken His
SLBP-15198M Recombinant Mouse SLBP Protein Mammalian Cell Mouse His
SLBP-7795H Recombinant Human SLBP, His-tagged HEK293 Human His
SLBP-8123Z Recombinant Zebrafish SLBP Mammalian Cell Zebrafish His
SLBP-8124Z Recombinant Zebrafish SLBP Mammalian Cell Zebrafish His
SLBP-596HCL Recombinant Human SLBP lysate HEK293 Human Non
SLBP-01H Recombinant Human SLBP Protein, C-Myc/DDK-tagged HEK293T Human Myc&DDK
Slbp-5901M Recombinant Mouse Slbp Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
SLBP-8209M Recombinant Mouse SLBP Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SLBP-8209M-B Recombinant Mouse SLBP Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SLBP involved in several pathways and played different roles in them. We selected most pathways SLBP participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA Polymerase II Transcription CSTF3,ZFP473,GM3258,CSTF1,LSM10,SRSF11,RNPS1,U2AF2,THOC4,CLP1
    Processing of Capped Intron-Containing Pre-mRNA SUGP1,BCAS2,CSTF1,WTAP,CCAR1,HNRNPA0,SF3B4,HNRNPA0L,HNRNPUL1,CSTF3
    Gene Expression NR5A1A,TYW1,EIF1AX,ZFP143,ZNF460,TAF1L,ZNF264,HENMT1,ZNF726,SNRNP25
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs ZNF473,LSM10,ZFP473,LSM11
    RNA Polymerase II Transcription Termination THOC4,SRSF11,CSTF2,RNPS1,U2AF2,PAPOLA,LSM11,ZFP473,NUDT21,ZNF473
    Processing of Capped Intronless Pre-mRNA CSTF2,CSTF3,CSTF1,LSM11,ZNF473,CLP1,PAPOLA,LSM10,ZFP473,NUDT21
    Transport of Mature Transcript to Cytoplasm SFRS3A,SRSF11,NXF1,U2AF2
    Cleavage of Growing Transcript in the Termination Region PAPOLA,U2AF2,NUDT21,LSM11,LSM10,THOC4,CLP1,CSTF1,SRSF11,CSTF3

    Protein Function

    SLBP has several biochemical functions, for example, histone pre-mRNA DCP binding,histone pre-mRNA stem-loop binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLBP itself. We selected most functions SLBP had, and list some proteins which have the same functions with SLBP. You can find most of the proteins on our site.

    Function Related Protein
    histone pre-mRNA stem-loop binding ERI1
    protein binding PEX6,SLC52A2,PEX11B,FYB,SULT1E1,PRKRIR,C17orf81,TDG,BTC,RXRG
    mRNA binding DPPA5A,RPL13A,PARK7,CELF1,EIF4ENIF1,PAIP2,HNRNPAB,FYTTD1,FMR1,SRRM4
    histone pre-mRNA DCP binding SNRPB,SNRPD3,LSM10
    poly(A) RNA binding FAM103A1,EIF4B,PHF5A,SAFB2,FUBP1,XRN1,PRRC2A,RBM25,SPATS2,TRIM25

    Interacting Protein

    SLBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLBP here. Most of them are supplied by our site. Hope this information will be useful for your research of SLBP.

    CDK4;CDK6;stem_loop_rna;ZNF473;TACC3

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