SKI
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Official Full Name
v-ski avian sarcoma viral oncogene homolog -
Overview
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009] -
Synonyms
SKI;v-ski avian sarcoma viral oncogene homolog;SGS;SKV;ski oncogene;ski oncoprotein;proto-oncogene c-Ski
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SKI-3376C | Recombinant Chicken SKI | Mammalian Cell | Chicken | His |
|
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| SKI-1815HCL | Recombinant Human SKI 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
SKI involved in several pathways and played different roles in them. We selected most pathways SKI participated on our site, such as BMP receptor signaling,C-MYB transcription factor network,Downregulation of SMAD2/3:SMAD4 transcriptional activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | GPBAR1,FMNL2,CRHB,SOX13,ADAM12,OPHN1,ARHGEF1A,FSTL1B,MYO9B,RXFP2B |
| Gene Expression | EIF2B1,SNAPC2,ZNF426,CTGF,ZNF615,MED15,SUPT16H,ZNF786,ZNF433,NRBP1 |
| Generic Transcription Pathway | ZIK1,ZNF562,NR5A1A,ZNF75A,ZNF79,ZNF398,ZNF43,ZNF480,NR1D2B,ZNF705A |
| BMP receptor signaling | RGMB,CTDSP1,SOSTDC1,CALML4,GREM1,RGMA,AHSG,CHRDL1,HFE2,CTDSPL |
| Regulation of nuclear SMAD2/3 signaling | GSC,FOXH1,NKX2,MYOD1,CBFB,CITED1,SNIP1 |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | SMAD3B,RNF111,USP9,SKILB,USP9X,SKIB,SKIA,TRIM33,PARP1 |
| C-MYB transcription factor network | PIAS3,MYF6,CDK6,LECT2,GATA1,MYB,TRIM28,CBX4,SLC25A3,CEBPB |
| Hedgehog signaling pathway | CSNK1G1,Shh,WNT6,SMO,WNT8A,GSK3AA,WNT2B,CSNK1G2B,RAB23,WNT5B |
Protein Function
SKI has several biochemical functions, for example, SMAD binding,chromatin binding,histone deacetylase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKI itself. We selected most functions SKI had, and list some proteins which have the same functions with SKI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| repressing transcription factor binding | HDAC1,CTBP1,TCF3,MYC,NOC2L,HMGB1,HDAC9,PRDM5,RUNX2,NFYB |
| SMAD binding | BMP2,COL5A2,ACVR1B,EID2,SKIL,SKIA,USP15,TGFBR1,PURA,COL3A1 |
| zinc ion binding | USP33,BTR12,MEX3C,ZNRF2B,ZFYVE19,SIAH2L,RARAA,RPS29,MMP24,NR1I3 |
| ubiquitin protein ligase binding | RNF40,USP2,TXNIP,CUL3B,TRIM37,CXCR4,DERL1,TRP53,SLC25A5,C10orf46 |
| protein kinase binding | PPME1,NPM1,MAML1,RHEB,IL12RB2,SYN1,JTB,TCF7L2,FBXO7,PKD1 |
| protein domain specific binding | TNFAIP1,YWHAH,KCNN2,YWHAB,NFE2L2,ARRB2,TBL1X,HIST1H4A,PHRF1,MECP2 |
| transcription corepressor activity | DMAP1,CTBP2A,SF1,HEYL,HIPK2,ATF7IP,TGIF1,RBFOX2,HDAC4,EID1 |
| chromatin binding | TLE4,SOX10,BRD4,EYA3,DNMT3A,TOX,NOC2L,MEF2C,PRDM13,KDM1A |
| histone deacetylase inhibitor activity | UCN |
Interacting Protein
SKI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKI here. Most of them are supplied by our site. Hope this information will be useful for your research of SKI.
SMAD3;SMAD4
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References
- Verbeke, SLJ; de Jong, D; et al. Array CGH Analysis Identifies Two Distinct Subgroups of Primary Angiosarcoma of Bone. GENES CHROMOSOMES & CANCER 54:72-81(2015).
- Mei, Y; Thompson, MD; et al. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 76:275-282(2014).
