SIPA1
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Official Full Name
signal-induced proliferation-associated 1 -
Overview
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. -
Synonyms
SIPA1;signal-induced proliferation-associated 1;signal-induced proliferation-associated protein 1;SPA1;sipa-1;p130 SPA-1;GTPase-activating protein Spa-1;signal-induced proliferation-associated gene 1;MGC17037;MGC102688
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIPA1-301389H | Recombinant Human SIPA1 protein, GST-tagged | E.coli | Human | GST | Gly950-Ala1042 |
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Involved Pathway
SIPA1 involved in several pathways and played different roles in them. We selected most pathways SIPA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SIPA1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SIPA1 itself. We selected most functions SIPA1 had, and list some proteins which have the same functions with SIPA1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
SIPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIPA1.
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References
- Zhang, Y; Gong, Y; et al. Nuclear SIPA1 activates integrin beta 1 promoter and promotes invasion of breast cancer cells. ONCOGENE 34:1451-1462(2015).
- Gdowicz-Klosok, A; Giglok, M; et al. The SIPA1-313A > G polymorphism is associated with prognosis in inoperable non-small cell lung cancer. TUMOR BIOLOGY 36:1273-1278(2015).
