SIM2
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Official Full Name
single-minded homolog 2 (Drosophila) -
Overview
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription;factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal;region. Based on the mapping position, its potential function as transcriptional repressor and similarity to;Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes. -
Synonyms
SIM2;single-minded homolog 2 (Drosophila);SIM, single minded (Drosophila) homolog 2;single-minded homolog 2;bHLHe15;MGC119447;transcription factor SIM2;Class E basic helix loop helix protein 15;Class E basic helix-loop-helix protein 15;SIM 2;SIM;SIM2_HUMAN;Single minded homolog 2 (Drosophila);Single minded homolog 2;OTTHUMP00000109043;OTTHUMP00000109044;single-minded homolog 2, short isoform;HMC13F06;HMC29C01
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIM2-2675H | Recombinant Human SIM2, GST-tagged | E.coli | Human | GST | 342-525aa | |
| SIM2-15140M | Recombinant Mouse SIM2 Protein | Mammalian Cell | Mouse | His |
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| SIM2-9344Z | Recombinant Zebrafish SIM2 | Mammalian Cell | Zebrafish | His |
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| SIM2-8176M | Recombinant Mouse SIM2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SIM2-8176M-B | Recombinant Mouse SIM2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SIM2 involved in several pathways and played different roles in them. We selected most pathways SIM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
SIM2 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIM2 itself. We selected most functions SIM2 had, and list some proteins which have the same functions with SIM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | TFDP1B,STAT6,MYCLA,TEFB,ZSCAN12,ZFP27,ZFP14,SOX13,ZNF92,PA2G4 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXD1L,MEF2C,SOX9A,NPAS1,SOX8B,FOXA3,TFE3A,MAZ,SIM1A,FOXQ1B |
| DNA binding | TBX5A,PDCD2,KDM5D,SIX4,GTF3A,SIX4B,ZNF669,TIGD6,DBN1,MUS81 |
| protein heterodimerization activity | HNF1B,HIST1H2AC,TLX1,SRY,ADD1,EGFR,BMP2,GCA,PVALB,HIST1H3G |
Interacting Protein
SIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIM2.
Dlg4;a8k1f4_human;b4dyc6_human;AIP;SGTA;BAG4;BAG2;HSPB1;HSP90AB1;STIP1;MLF1;PSMD2;FKBP5;PTGES3;HSP90AB1;NUDCD3;Hacd3;q96be0_human;TTC1;PPP5C
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References
- Spellman, C; Ahmed, MM; et al. Expression of trisomic proteins in Down syndrome model systems. GENE 512:219-225(2013).
- Arredouani, MS; Lu, B; et al. Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer. CLINICAL CANCER RESEARCH 15:5794-5802(2009).
