SIL1
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Official Full Name
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) -
Overview
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. -
Synonyms
SIL1;SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae);Marinesco Sjogren syndrome , MSS;nucleotide exchange factor SIL1;BAP;ULG5;BiP Associated Protein;BiP-associated protein;Endoplasmic reticulum chaperone SIL 1;Endoplasmic Reticulum Chaperone SIL1;MSS;Nucleotide exchange factor SIL 1;SIL 1;SIL1 homolog;SIL1 homolog endoplasmic reticulum chaperone (S. cerevisiae);SIL1 homolog endoplasmic reticulum chaperone;SIL1_HUMAN
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SIL1 involved in several pathways and played different roles in them. We selected most pathways SIL1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CAPN1B,CAPN2A,BCL2A,BAG2,MAPK8B,DNAJC5G,TXNDC5,DNAJB1B,DNAJC5B,UBE2J1 |
Protein Function
SIL1 has several biochemical functions, for example, adenyl-nucleotide exchange factor activity,protein binding,unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIL1 itself. We selected most functions SIL1 had, and list some proteins which have the same functions with SIL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| adenyl-nucleotide exchange factor activity | GRPEL1,GRPEL2,PFN2,HSPBP1,PFN1 |
| unfolded protein binding | HSPE1,GRXCR2,CALR3,HSP90AA1,DNAJB8,CLGN,CCT2,SCG5,HSPA9,PTGES3 |
| protein binding | SLC1A1,SETD7,EIF4E,KHDC1A,ILVBL,USP47,GAB1,WRAP53,SLIT2,C4orf19 |
Interacting Protein
SIL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIL1.
UBQLN1;SMAD9;CCND3;q7cl26_yerpe;Kat8
Resources
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References
- Ichhaporia, VP; Sanford, T; et al. Sil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretion. MOLECULAR BIOLOGY OF THE CELL 26:420-429(2015).
