SIGLEC1
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Official Full Name
sialic acid binding Ig-like lectin 1, sialoadhesin -
Overview
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule;that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane;protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions.;Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound;;however, the full-length nature of this variant has not been determined. -
Synonyms
SIGLEC1;sialic acid binding Ig-like lectin 1, sialoadhesin;sialoadhesin , SN;sialoadhesin;CD169;dJ1009E24.1;FLJ00051;FLJ00055;FLJ00073;FLJ32150;SIGLEC 1;sialic acid-binding Ig-like lectin 1;sialic acid-binding immunoglobulin-like lectin 1;SN;SIGLEC-1;FLJ00411;DKFZp667F058
Recombinant Proteins
- Mouse
- Human
- Pig
- Mammalian cells
- E.coli
- HEK293
- HEK293T
- Fc
- His
- His&Myc
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
SIGLEC1 involved in several pathways and played different roles in them. We selected most pathways SIGLEC1 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | ICOSLG,Itgam&Itgb2,CLDN19,OCLNA,HLA-DQA1,NRCAM,MHC1UEA,CLDND,NLGN4A,Ntng2 |
Protein Function
SIGLEC1 has several biochemical functions, for example, carbohydrate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC1 itself. We selected most functions SIGLEC1 had, and list some proteins which have the same functions with SIGLEC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DNAJA1,LAMTOR2,CACFD1,EPCAM,RPL39L,GSN,SMAD2,PRKAG1,CYB561,TGM1 |
| carbohydrate binding | KLRD1,SIGLEC6,GALNT7,REG1B,KLRB1A,CLEC7A,PKD1L3,ASGR2,APCS,FCNA |
Interacting Protein
SIGLEC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC1.
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