SIAH2
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Official Full Name
siah E3 ubiquitin protein ligase 2 -
Overview
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008] -
Synonyms
SIAH2;siah E3 ubiquitin protein ligase 2;hSiah2;E3 ubiquitin-protein ligase SIAH2;siah-2;seven in absentia homolog 2
Recombinant Proteins
- Mouse
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
SIAH2 involved in several pathways and played different roles in them. We selected most pathways SIAH2 participated on our site, such as Axon guidance,Developmental Biology,Netrin-1 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Netrin-1 signaling | RNF8,NTN1B,RGMB,EZRA,PITPNA,RGMA,TRPC4,UNC5D,TRPC5,NTN1A |
| Axon guidance | NRP1,CXCR4,MARK3,SPTBN1,EPHA3,CFL1,FGFR1B,SEMA3D,CSK,KCNQ2 |
| Parkin-Ubiquitin Proteasomal System pathway | TUBA3E,TUBA1B,STUB1,TUBB7P,HSPA7,UBE2J2,TUBA3D,RNF19A,HSPA14 |
| Developmental Biology | SCN3B,EGR2,LEFTY1,NR2F2,EPHB4B,NRG3,GPC1A,SREBF2,INSM1B,DNM2 |
Protein Function
SIAH2 has several biochemical functions, for example, ligase activity,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAH2 itself. We selected most functions SIAH2 had, and list some proteins which have the same functions with SIAH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | NEUROD2,NR0B1,TMEM38A,SRSF2,HSF4,SSX2,HIPK2,SKOR1B,CBFA2T2,HAND1 |
| ubiquitin protein ligase activity | MED7,TRIM37,MDM2,UBE2V1,UBE2C,MGRN1,MSL2A,FBXL22,C12orf51,RNF121 |
| ubiquitin conjugating enzyme binding | RNF180,TRIM72,ANKIB1,RNF144AB,RNF14,RNF217,RNF40,UBE2V1,ZMYM2,RNF144AA |
| ligase activity | RFWD3,TRIM39,TOPORS,MUL1A,TRIM32,CMTM2A,ARIH1,NSMCE1,PELI3,NEDD4 |
| zinc ion binding | BTR12,TRIM109,HNF4A,RNF19A,CA2,PPARD,TRIM44,ZCCHC17,SOD1,PDZRN4 |
| protein binding | LCE1B,FCER1G,RRP8,CEP290,SCAMP5,PIAS3,BNIP3,UBB,MACROD1,CDCA4 |
Interacting Protein
SIAH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAH2.
OPRM1;SH3RF1;MYD88;Oprd1;OPRK1;EEF1D;STAT3;ATN1;UBE2I;Pou2af1;CCBE1;SETD2;HIPK3;CACYBP;ppap_human_gene;fxyd3_human_gene
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References
- Tan, JTM; Prosser, HCG; et al. High- density lipoproteins augment hypoxia-induced angiogenesis via regulation of post- translational modulation of hypoxia- inducible factor 1 alpha. FASEB JOURNAL 28:206-217(2014).
- MacLeod, RJ; Hayes, M; et al. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 293:G403-G411(2007).
