SIAE
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Official Full Name
sialic acid acetylesterase -
Overview
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene. -
Synonyms
SIAE;sialic acid acetylesterase;YSG2, Ysg2 homolog (mouse);sialate O-acetylesterase;CSE C;LSE;MGC87009;sialic acid specific acetylesterase II;CSEC;Cytosolic sialic acid 9 O acetylesterase homolog;H Lse;HLse;Sialate O acetylesterase;Sialic acid specific 9 O acetylesterase;YSG2;Ysg2 homolog;H-Lse;sialic acid-specific acetylesterase II;cytosolic sialic acid 9-O-acetylesterase homolog;AIS6;CSE-C
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- HEK293
- Mammalian Cell
- Insect Cells
- Insect Cell
- Recombinant Full Length Human sialic acid acetylesterase protein with a C-terminal 6-His tag was expressed in Chinese Hamster Ovary cell line.
- Mammalian cells
- HEK293T
- His&GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
SIAE involved in several pathways and played different roles in them. We selected most pathways SIAE participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SIAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SIAE has several biochemical functions, for example, sialate O-acetylesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIAE itself. We selected most functions SIAE had, and list some proteins which have the same functions with SIAE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SIAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIAE here. Most of them are supplied by our site. Hope this information will be useful for your research of SIAE.
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References
- Yamamoto, M; Iguchi, G; et al. A missense single-nucleotide polymorphism in the sialic acid acetylesterase (SIAE) gene is associated with anti-PIT-1 antibody syndrome. ENDOCRINE JOURNAL 61:641-644(2014).
- Pituch-Noworolska, A; Blaut-Szlosarczyk, A; et al. Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency. PRZEGLAD GASTROENTEROLOGICZNY 8:370-376(2013).
- Speletas, M; Sevdali, E; et al. SIALIC ACID ACETYLESTERASE (SIAE) MUTATIONS ARE NOT ASSOCIATED WITH AUTOIMMUNE DISEASE RISK IN PATIENTS WITH ANTIBODY DEFICIENCIES. JOURNAL OF CLINICAL IMMUNOLOGY 32:403-404(2012).
- Pillai, S; Mattoo, H; et al. B cells and autoimmunity. CURRENT OPINION IN IMMUNOLOGY 23:721-731(2011).
