SHPK
-
Official Full Name
sedoheptulokinase -
Overview
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. -
Synonyms
SHPK;sedoheptulokinase;carbohydrate kinase like , CARKL;SHK;Carbohydrate kinase like;Carbohydrate kinase like protein;Carbohydrate kinase-like protein;CARKL;SHPK_HUMAN;OTTHUMP00000115862
Recombinant Proteins
- Human
- Wheat Germ
- Insect Cell
- Insect Cells
- In Vitro Cell Free System
- Mammalian cells
- GST
- His
- Non
- His&GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHPK-1329H | Recombinant Human SHPK Protein, GST-Tagged | Wheat Germ | Human | GST |
|
|
| SHPK-244H | Recombinant Human SHPK, His-GST tagged | Insect Cell | Human | His | 2-478 a.a. |
|
| SHPK-265H | Recombinant Human SHPK, Gly&Pro tagged | Insect Cell | Human | His | 2-478 a.a. |
|
| SHPK-001HCL | Recombinant Human SHPK cell lysate | Insect Cell | Human | Non |
|
|
| SHPK-002HCL | Recombinant Human SHPK cell lysate | Insect Cell | Human | Non |
|
|
| SHPK-2205H | Recombinant Human SHPK protein, His&GST-tagged | Insect Cells | Human | His&GST | Ala2-Ser478 |
|
| SHPK-3519HF | Recombinant Full Length Human SHPK Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 478 amino acids |
|
| SHPK-5781H | Recombinant Human SHPK Protein (Met1-Ser478), C-His tagged | Mammalian cells | Human | His | Met1-Ser478 |
|
Involved Pathway
SHPK involved in several pathways and played different roles in them. We selected most pathways SHPK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SHPK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SHPK has several biochemical functions, for example, ATP binding,sedoheptulokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SHPK itself. We selected most functions SHPK had, and list some proteins which have the same functions with SHPK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CHTF18,MVD,IKBKB,ABCB6,NEK11,SCYL3,DCLK2,ABCB3L1,HSPA1B,AKT3A |
Interacting Protein
SHPK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHPK here. Most of them are supplied by our site. Hope this information will be useful for your research of SHPK.
MDM2
Resources
Related Services
Related Products
References
- Wamelink, MMC; Struys, EA; et al. Elevated concentrations of sedoheptulose in bloodspots of patients with cystinosis caused by the 57-kb deletion: Implications for diagnostics and neonatal screening. MOLECULAR GENETICS AND METABOLISM 102:339-342(2011).
- Wamelink, MMC; Struys, EA; et al. Sedoheptulokinase deficiency due to a 57-KB deletion in cystinosis patients causes accumulation of sedoheptulose: elucidation of the function of the carkl gene. PEDIATRIC NEPHROLOGY 24:905-905(2009).
