SHC3
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Official Full Name
SHC (Src homology 2 domain containing) transforming protein 3 -
Overview
SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene. -
Synonyms
SHC3;SHC (Src homology 2 domain containing) transforming protein 3;src homology 2 domain containing transforming protein C3;SHC-transforming protein 3;N Shc;NSHC;SHCC;N-Shc;Neuronal Shc;Protein Rai;Rai;SH2 domain protein C3;SHC protein C;SHC-like protein, neuronal;SHC-transforming protein C;SHC3_HUMAN;Src homology 2 domain-containing transforming protein;Src homology 2 domain-containing-transforming protein C3;src homology 2 domain-containing transforming protein C3
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- GST
- His&GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHC3-2655H | Recombinant Human SHC3, GST-tagged | E.coli | Human | GST | C-term-351aa | |
| SHC3-1277H | Recombinant Human SHC3 protein, His & GST-tagged | E.coli | Human | His&GST | Val188~Gln433 |
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| SHC3-15092M | Recombinant Mouse SHC3 Protein | Mammalian Cell | Mouse | His |
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| SHC3-4193R | Recombinant Rhesus monkey SHC3 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SHC3-1602HCL | Recombinant Human SHC3 cell lysate | Human | Non |
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| SHC3-4009R | Recombinant Rhesus Macaque SHC3 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SHC3-4009R-B | Recombinant Rhesus Macaque SHC3 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SHC3-5922H | Recombinant Human SHC3 Protein (Val188-Gln433), N-GST tagged | E.coli | Human | GST | Val188-Gln433 |
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| SHC3-8143M | Recombinant Mouse SHC3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SHC3-8143M-B | Recombinant Mouse SHC3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SHC3 involved in several pathways and played different roles in them. We selected most pathways SHC3 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | GRB2A,PTK2,HRASA,SHC2,PTK2AA,KRAS,MAPK8B,NRG1,SOS1,RAF1A |
| Chronic myeloid leukemia | STAT5A,MAP2K2,SMAD4,CCND1,MAPK3,TP53,RELA,TGFBR1,PIK3CB,CBLB |
| Ras signaling pathway | PIK3CG,PAK3,PLCE1,RGL1,TBK1,FGF5,PIK3CB,GNB1,KRAS,INS |
| Phospholipase D signaling pathway | AKT2,PTK2B,CYTH4,PPAP2A,Adcy4,PLD2,PIP5K1A,SYK,PLD1,PDGFA |
| Insulin signaling pathway | PPP1CC,RPS6KB2,G6PC,PPP1R3A,HRAS,IRS4,RPTOR,PRKAB2,PPP1CAB,FLOT2B |
| Neurotrophin signaling pathway | ARHGDIB,CAMK2D,MAGED1,GAB1,MAP3K5,MAP3K3,NFKBIE,GSK3B,PIK3R1,MAPK13 |
| Focal adhesion | FYN,MYLK2,IGF1RB,COL1A1B,BRAF,TNK1,MAPK8B,PPP1R12C,LAMA5,ACTN2B |
| Glioma | PRKCA,MDM2,PDGFB,CALML3,CAMK2A,TP53,CALM1,IGF1,CALM4,PIK3CG |
| Estrogen signaling pathway | CALM1,GNAI3,PIK3R1,KRAS,HSPA1L,HSP90AA1,ATF4,SP1,ESR2,PIK3CB |
Protein Function
SHC3 has several biochemical functions, for example, protein binding,protein kinase binding,receptor tyrosine kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHC3 itself. We selected most functions SHC3 had, and list some proteins which have the same functions with SHC3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | VMN1R44,TAS2R137,PTK2,VMN1R47,LPAR2B,GNA12,PTK2BB,ECT2,GNA15.4,S100A9 |
| receptor tyrosine kinase binding | SHC4,Flt3l,ANGPT2,DOCK4,ANGPT4,SOCS5,ZFP259,LRP4,PIK3R2,ARHGEF16 |
| protein kinase binding | BCL2L1,ACTA2,PTK2,PXN,RICTOR,E2F1,PRKACA,EMP2,SUFU,TENC1 |
| protein binding | KIAA0101,NCAM1A,KCNH1,LAGE3,GLRB,VAMP4,MSI2,ZNF543,BSCL2,KRT2 |
Interacting Protein
SHC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHC3.
GOLGA2;KRT31;KRT40;EGFR;ERBB2;MET;AR;KIT;ERBB3;GAB1
SHC3 Related Signal Pathway
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References
- Adams, SJ; Aydin, IT; et al. GAB2-a Scaffolding Protein in Cancer. MOLECULAR CANCER RESEARCH 10:1265-1270(2012).
- Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).
