SHANK3
-
Official Full Name
SH3/ankyrin domain gene 3 -
Overview
SH3 and multiple ankyrin repeat domains 3, also known as SHANK3, is a human gene on chromosome 22. -
Synonyms
SHANK3;SH3/ankyrin domain gene 3;SH3 and multiple ankyrin repeat domains protein 3;AI841104;DEL22q13.3;KIAA1650;Proline rich synapse associated protein 2;ProSAP2;PSAP2;SH3 and multiple ankyrin repeat domains 3;Shank postsynaptic density protein;Shank3b;SPANK 2;SPANK2;SPANK-2;proline-rich synapse-associated protein 2
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- Human cells
- Yeast
- E.coli
- HEK293
- HEK293T
- His
- Flag
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHANK3-15086M | Recombinant Mouse SHANK3 Protein | Mammalian Cell | Mouse | His |
|
|
| SHANK3-5387R | Recombinant Rat SHANK3 Protein | Mammalian Cell | Rat | His |
|
|
| SHANK3-01M | Recombinant Mouse SHANK3 Protein, Flag-tagged | Human cells | Human | Flag |
|
|
| SHANK3-12M | Recombinant Mouse SHANK3 Protein | Yeast | Mouse | 533 to 665 aa |
|
|
| SHANK3-301390H | Recombinant Human SHANK3 protein, GST-tagged | E.coli | Human | GST | Met358-Ala457 |
|
| SHANK3-5046R | Recombinant Rat SHANK3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| SHANK3-5046R-B | Recombinant Rat SHANK3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Shank3-5852M | Recombinant Mouse Shank3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
|
| SHANK3-8137M | Recombinant Mouse SHANK3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| SHANK3-8137M-B | Recombinant Mouse SHANK3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SHANK3 involved in several pathways and played different roles in them. We selected most pathways SHANK3 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHANK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GNAI3,GRM1,SLC38A2,SLC1A2,PPP3CA,SLC17A6,SLC1A1,GNAS,GNG11,GRIN2B |
Protein Function
SHANK3 has several biochemical functions, for example, GKAP/Homer scaffold activity,SH3 domain binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHANK3 itself. We selected most functions SHANK3 had, and list some proteins which have the same functions with SHANK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ionotropic glutamate receptor binding | SHANK2,SHANK1,DLG1,DLG1L,FUS,CACNG2,DLG4,CANX,FLOT2,GNAS |
| protein binding | DHX30,NAP1L2,PIK3CD,ZNF227,HTR3A,NCALD,CD5,ACTN1,SRGN,SMCO4 |
| SH3 domain binding | SH2D2A,SHANK1,CNTNAP1,ARHGAP6,NOXA1,PDCD6IP,UVRAG,DENND1A,BCAR1,PLSCR1 |
| protein C-terminus binding | PQBP1,VPS4B,NEFL,DLG3,PFKM,PROP1,PPM1A,CALCOCO1,TFCP2,SHANK2 |
| actin binding | SSH3,FSCN2B,IPP,MYO19,GAS2L3,VCL,ABLIM1B,PALLD,KLHL20,HOMER2 |
| identical protein binding | NUP153,GOT2B,L1CAM,TRIP13,ESYT2,HOMER1,ERBB3,DPY30,ZHX2,ADIPOR1 |
| zinc ion binding | LONRF1L,TADA2B,PJA1,CBLB,KIAA0913,LHX1A,ING5,PDLIM5B,KDM5D,CPE |
| GKAP/Homer scaffold activity | SHANK1,HOMER2 |
| protein self-association | AGXT,RSAD2,ABCD3,AGTR1A,ZNF496,MALT1,SVIP,CTSC,TMEM43,ACHE |
Interacting Protein
SHANK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHANK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHANK3.
Shank1;Nphp4;Ywhae;Ywhab;Bsn
Resources
Related Services
Related Products
References
- Kouser, M; Speed, HE; et al. Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission. JOURNAL OF NEUROSCIENCE 33:18448-18468(2013).
- Raab, M; Boeckers, TM; et al. PROLINE-RICH SYNAPSE-ASSOCIATED PROTEIN-1 AND 2 (ProSAP1/Shank2 AND ProSAP2/Shank3)-SCAFFOLDING PROTEINS ARE ALSO PRESENT IN POSTSYNAPTIC SPECIALIZATIONS OF THE PERIPHERAL NERVOUS SYSTEM. NEUROSCIENCE 171:421-433(2010).
