SHANK1
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Official Full Name
SH3 and multiple ankyrin repeat domains 1 -
Overview
SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene. -
Synonyms
SHANK1;SH3 and multiple ankyrin repeat domains 1;SH3 and multiple ankyrin repeat domains protein 1;somatostatin receptor interacting protein;SPANK 1;SSTRIP;synamon;SSTR-interacting protein;somatostatin receptor-interacting protein;SPANK-1
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cell
- E. coli
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHANK1-15084M | Recombinant Mouse SHANK1 Protein | Mammalian Cell | Mouse | His |
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| SHANK1-5385R | Recombinant Rat SHANK1 Protein | Mammalian Cell | Rat | His |
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| SHANK1-26H | Recombinant Human SHANK1 protein, His-tagged | E. coli | Human | His | 1-625aa |
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| SHANK1-5044R | Recombinant Rat SHANK1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SHANK1-5044R-B | Recombinant Rat SHANK1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SHANK1-8135M | Recombinant Mouse SHANK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SHANK1-8135M-B | Recombinant Mouse SHANK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SHANK1 involved in several pathways and played different roles in them. We selected most pathways SHANK1 participated on our site, such as Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHANK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | PRKACG,PLCB1,TRPC1,GRM1,GRM7,GNG8,GRIN2A,GRM3,GRIK2,GRIN3B |
Protein Function
SHANK1 has several biochemical functions, for example, GKAP/Homer scaffold activity,SH3 domain binding,ankyrin repeat binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHANK1 itself. We selected most functions SHANK1 had, and list some proteins which have the same functions with SHANK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein C-terminus binding | PHB,VGLL1,CAV3,VTA1,XRCC5,LCK,ERCC3,PXK,ITPR1,YWHAQ |
| SH3 domain binding | CABYR,ARHGAP27,CNTNAP1,SIRPA,SOS1,BCAR1,PLSCR4,ILK,KHDRBS3,NCF1 |
| ionotropic glutamate receptor binding | CANX,CACNG2,DLG3,ADRB2,DLG4B,RAB4A,DLG2,FUS,FLOT2,SHANK3 |
| GKAP/Homer scaffold activity | SHANK3,HOMER2 |
| scaffold protein binding | NOS1,KRT18,SRC,DSP,CHRNA7,DLG4,NOS3,KRT5,CASP8,PARK7 |
| protein complex binding | TXN2,ITGB1BP1,CFLAR,GNB2,PDCL,UQCRC1,CPS1,PTPRF,SREBF1,NDUFA9 |
| ankyrin repeat binding | HIF1AN,RELA |
| identical protein binding | IIGP1,SMAD6,ADIPOR1,SEPHS1,GRIN3A,UBQLN4,GCC2,MYOM1,TPCN1,GBP5 |
| receptor signaling complex scaffold activity | SPAG9A,NUP62,CD3E,SPAG9,ROPN1B,LDLRAP1,AXIN1,CARD10,RGS14,NCK2 |
Interacting Protein
SHANK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHANK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHANK1.
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References
- Tao-Cheng, JH; Dosemeci, A; et al. ACTIVITY INDUCED CHANGES IN THE DISTRIBUTION OF SHANKS AT HIPPOCAMPAL SYNAPSES. NEUROSCIENCE 168:11-17(2010).
- Uemura, T; Mori, H; et al. Direct interaction of GluR delta 2 with Shank scaffold proteins in cerebellar Purkinje cells. MOLECULAR AND CELLULAR NEUROSCIENCE 26:330-341(2004).
- Lim, S; Naisbitt, S; et al. Characterization of the Shank family of synaptic proteins - Multiple genes, alternative splicing, and differential expression in brain and development. JOURNAL OF BIOLOGICAL CHEMISTRY 274:29510-29518(1999).
