SH3BP2
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Official Full Name
SH3-domain binding protein 2 -
Overview
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SH3BP2;SH3-domain binding protein 2;Cherubism;SH3 domain-binding protein 2;CRBM;RES4 23;CRPM;FLJ42079;FLJ54978;3BP-2;3BP2;3BP2_HUMAN;Abl SH3 binding protein 2;RES4-23;SH3 domain binding protein 2;TNFAIP3 interacting protein 2;OTTHUMP00000219014;OTTHUMP00000219024;OTTHUMP00000219026;OTTHUMP00000219027;Abl-SH3 binding protein 2
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- E. coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- N-GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SH3BP2-9178H | Recombinant Human SH3BP2, His-tagged | E.coli | Human | His | 1-301a.a. | |
| AKR1C3-9533H | Recombinant Human AKR1C3 protein, GST-tagged | E. coli | Human | N-GST | 1-323 aa | |
| SH3BP2-2833C | Recombinant Chicken SH3BP2 | Mammalian Cell | Chicken | His |
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| SH3BP2-1871HCL | Recombinant Human SH3BP2 293 Cell Lysate | HEK293 | Human | Non |
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| SH3BP2-2359H | Recombinant Human SH3BP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Sh3bp2-5841M | Recombinant Mouse Sh3bp2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SH3BP2-6280H | Recombinant Human SH3BP2 Protein (Met1-Leu259), N-His tagged | E.coli | Human | His | Met1-Leu259 |
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| SH3BP2-708H | Recombinant Human SH3BP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
SH3BP2 involved in several pathways and played different roles in them. We selected most pathways SH3BP2 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH3BP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | HLA-E,KIR3DL2,PIK3CB,ITGAL,MAP2K1,RAET1G,Fasl,PRKCB,ICAM2,LCP2 |
Protein Function
SH3BP2 has several biochemical functions, for example, SH3 domain binding,SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH3BP2 itself. We selected most functions SH3BP2 had, and list some proteins which have the same functions with SH3BP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | AFAP1L2,SHANK1,SOS1,FMNL3,SH2D2A,GPX1,EVLB,DOCK4,ZFP106,SGIP1 |
| SH3/SH2 adaptor activity | GRB10,ITSN2,CNTNAP1,RUSC1,PTPN11,CD28,SH2D1A,SH2D3A,CRK,STAP1 |
| protein binding | SYT17,POLB,DLAT,DAXX,FBXW11,CDC42BPG,SMPD1,ZNF202,UBA7,CDK16 |
Interacting Protein
SH3BP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH3BP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH3BP2.
VAV1;VAV2;DBNL
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