SH2D2A
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Official Full Name
SH2 domain containing 2A -
Overview
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. -
Synonyms
SH2D2A;SH2 domain containing 2A;SH2 domain protein 2A;SH2 domain-containing protein 2A;F2771;T cell specific adapter protein TSAd;T cell specific adpater protein TSAd;T lymphocyte specific adaptor protein;TSAd;SCAP;SH2 domain containing adapter protein;SH2 domain containing protein 2A;T cell specific adapter protein;VEGF receptor associated protein;VRAP;VEGF receptor-associated protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SH2D2A-1878HCL | Recombinant Human SH2D2A 293 Cell Lysate | HEK293 | Human | Non |
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| SH2D2A-1415HFL | Recombinant Full Length Human SH2D2A Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| SH2D2A-2002H | Recombinant Human SH2D2A Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SH2D2A-2002H-B | Recombinant Human SH2D2A Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| Sh2d2a-5835M | Recombinant Mouse Sh2d2a Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
SH2D2A involved in several pathways and played different roles in them. We selected most pathways SH2D2A participated on our site, such as VEGF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| VEGF signaling pathway | MAPKAPK3,PIK3R3,MAPK14B,MAP2K1,CDC42L2,BAD,PTK2AB,NOS3,PIK3R3B,BADB |
Protein Function
SH2D2A has several biochemical functions, for example, SH3 domain binding,SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D2A itself. We selected most functions SH2D2A had, and list some proteins which have the same functions with SH2D2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | RUSC1,GRB14,SH3BGRL,HSH2D,LAT,SH2D3A,EPS8,IRS4,CRKL,SRC |
| SH3 domain binding | LANCL1,SHANK3,SGIP1,MAPT,SH3BP1,CD3E,ADAM12,QKIA,ITGB1BP2,INPPL1B |
| protein binding | ERCC1,MORN3,FHIT,AZIN1,CIDEB,MUC7,ZFP259,CSTF1,PHF21A,SOX4 |
Interacting Protein
SH2D2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D2A here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D2A.
LCK;FSBP;PIK3R1;PTK2
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References
- Lee, H; Guo, J; et al. Identification of an immunoreceptor tyrosine-based activation motif of K1 transforming protein of Kaposi's sarcoma-associated herpesvirus. MOLECULAR AND CELLULAR BIOLOGY 18:5219-5228(1998).
- Luttrell, LM; DellaRocca, GJ; et al. G beta gamma subunits Src-dependent phosphorylation of the epidermal growth factor receptor - A scaffold for G protein-coupled receptor-mediated Ras activation. JOURNAL OF BIOLOGICAL CHEMISTRY 272:4637-4644(1997).
- PEREZ, L; URICH, M; et al. DOMAINS IN MIDDLE-T ANTIGEN THAT COOPERATE IN POLYOMAVIRUS-MEDIATED ONCOGENIC TRANSFORMATION. VIROLOGY 208:26-37(1995).
