SH2D1B
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Official Full Name
SH2 domain containing 1B -
Overview
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal;transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 (PubMed;11689425)). -
Synonyms
SH2D1B;SH2 domain containing 1B;SH2 domain-containing protein 1B;EAT2;EAT 2;EWS/FLI1 activated transcript 2;SH2 domain containing molecule EAT2;SH2 domain containing protein 1B;EAT-2;EWS/FLI1-activated transcript 2;SH2 domain-containing molecule EAT2
Recombinant Proteins
- Human
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SH2D1B-2640H | Recombinant Human SH2D1B, GST-tagged | E.coli | Human | GST | 1-132aa | |
| SH2D1B-5343C | Recombinant Chicken SH2D1B | Mammalian Cell | Chicken | His |
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| SH2D1B-1597HCL | Recombinant Human SH2D1B cell lysate | Human | Non |
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| SH2D1B-1337H | Recombinant Human SH2D1B Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SH2D1B-2001H | Recombinant Human SH2D1B Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SH2D1B-2001H-B | Recombinant Human SH2D1B Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SH2D1B-210H | Recombinant Human SH2D1B Protein, His-tagged | Insect Cell | Human | His | 1-132aa |
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| SH2D1B-2183HFL | Recombinant Full Length Human SH2D1B Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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Involved Pathway
SH2D1B involved in several pathways and played different roles in them. We selected most pathways SH2D1B participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | LAIR1,CD300LB,KLRG1,CLEC2H,SIGLEC7,AF251705,AMICA1,CD300C,GM11711,CD226 |
| Adaptive Immune System | RNF220,SEC61B,FGF8B,ACTR1A,LAIR1,AGO3,SRMS,GRAP2A,CD226,CYBA |
| Immune System | CD300C,TRIM56,TREX1,TLR10,CASPB,CLEC6A,SPSB4,SAMHD1,ADAR,LAT2 |
| Natural killer cell mediated cytotoxicity | RAET1L,SHC1,TNFRSF10D,ITGAL,PIK3R2,MAPK3,Raet1a,IFNA10,MAPK1,ITGB2L |
Protein Function
SH2D1B has several biochemical functions, for example, protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D1B itself. We selected most functions SH2D1B had, and list some proteins which have the same functions with SH2D1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | ST13,RAD50,ANK2,SYNM,FSCN1A,FGA,CRADD,TNNT2A,TRIM17,CUX1 |
| protein binding | TRIM38,ZHX1,TIMM21,INTS5,NSMCE2,PPP2R5C,HNRPLL,CSF1,SP3,PIK3R1 |
Interacting Protein
SH2D1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D1B.
q53hf2_human;TRIM54;CD84;OLIG1;STAT4;ERBB2;MET
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References
- Kurzer, JH; Argetsinger, LS; et al. Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. MOLECULAR AND CELLULAR BIOLOGY 24:4557-4570(2004).
