SH2B1

  • Official Full Name

    SH2B adaptor protein 1

  • Overview

    This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.

  • Synonyms

    SH2B1;SH2B adaptor protein 1;SH2B adapter protein 1;FLJ30542;SH2 B homolog;SH2B;DKFZp547G1110;KIAA1299;Pro-rich, PH and SH2 domain-containing signaling mediator;PSM;SH2 B;SH2 domain-containing protein 1B;SH2 domain-containing putative adapter SH2-B;SH2-B signaling protein;SH2B1 protein

Recombinant Proteins

  • Mouse
  • Rat
  • Zebrafish
  • Human
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SH2B1-15051M Recombinant Mouse SH2B1 Protein Mammalian Cell Mouse His
SH2B1-5371R Recombinant Rat SH2B1 Protein Mammalian Cell Rat His
SH2B1-6176Z Recombinant Zebrafish SH2B1 Mammalian Cell Zebrafish His
SH2B1-1596HCL Recombinant Human SH2B1 cell lysate Human Non
SH2B1-1340H Recombinant Human SH2B1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
SH2B1-5030R Recombinant Rat SH2B1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
SH2B1-5030R-B Recombinant Rat SH2B1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Sh2b1-5832M Recombinant Mouse Sh2b1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
SH2B1-8113M Recombinant Mouse SH2B1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SH2B1-8113M-B Recombinant Mouse SH2B1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SH2B1 involved in several pathways and played different roles in them. We selected most pathways SH2B1 participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neurotrophin signaling pathway MAPK3,NTRK3,CALM4,ATF4,GAB1,HRAS,BDNF,PIK3CD,BAD,AKT1

    Protein Function

    SH2B1 has several biochemical functions, for example, protein binding,signal transducer activity,signaling adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2B1 itself. We selected most functions SH2B1 had, and list some proteins which have the same functions with SH2B1. You can find most of the proteins on our site.

    Function Related Protein
    signaling adaptor activity SH2B2,AFAP1L2,SH2B3,GNB2L1,MPP7,LDLRAP1,HOMER1
    protein binding JAG1,ORC1L,CDX1,DNAJA3,ZFP488,RING1,PYGO2,FMNL1,ZNF643,SULT1E1
    signal transducer activity TAAR14A,NPY8AR,TAAR7F,GPR132B,TAAR11,VMN1R49,OLFR486,RHOC,MUL1A,GPR31B

    Interacting Protein

    SH2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2B1.

    EGFR;JAK2;Stat3;INSR;MET;STAT3;Stat3;KIAA0319

    Resources

    Research Area

    Adaptor Proteins
    Adaptor Proteins in the Akt Pathway
    Negative Regulators of the Jak/STAT Pathway
    Positive Regulators of the Jak/STAT Pathway

    References

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