SGMS2
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Official Full Name
sphingomyelin synthase 2 -
Overview
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined. -
Synonyms
SGMS2;sphingomyelin synthase 2;phosphatidylcholine:ceramide cholinephosphotransferase 2;MGC26963;SMS2;SGMS 2;SM synthase;SMS 2;SMS2_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Cynomolgus
- Macaca fascicularis
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- Insect cell
- Wheat Germ
- In Vitro Cell Free System
- His
- mFc
- Non
- StrepII
- His&Fc&Avi
- GST
Involved Pathway
SGMS2 involved in several pathways and played different roles in them. We selected most pathways SGMS2 participated on our site, such as Metabolic pathways,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid metabolism | GLA,CERK,ASAH2,ASAH1A,ACER1,GLTP,DEGS2,GALCB,NEU1,PPAP2A |
| Metabolism of lipids and lipoproteins | APOF,MED9,GLIPR1,APOC2,CYP4F11,AWAT1,CYP46A1,PHOSPHO1,GDF1,PPM1LB |
| Metabolism | COX10,PLCD3,CYGB,CKMB,BCHE,SCO1,SLC25A2,ARSD,CYP24A1,CEPT1A |
| Metabolic pathways | GALNT12,ENO1,HMGCRB,PPCDC,ACOT1,SPHK2,ATP6V0B,NME2B.1,AGL,COX15 |
| Sphingolipid de novo biosynthesis | PPM1L,CERS4A,VAPB,CERS3B,FA2H,PPM1LA,OSBP,SPTLC1,GDF1,COL4A3BP |
| Sphingolipid signaling pathway | PLD1,TP53,FCER1G,PPP2R1B,RAC1,PIK3CA,ASAH2,TRP53,PIK3R3,DEGS2 |
Protein Function
SGMS2 has several biochemical functions, for example, ceramide cholinephosphotransferase activity,kinase activity,sphingomyelin synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGMS2 itself. We selected most functions SGMS2 had, and list some proteins which have the same functions with SGMS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ceramide cholinephosphotransferase activity | SGMS1 |
| sphingomyelin synthase activity | SGMS1 |
| kinase activity | TSSK1,MAPKAPK2B,GM4922,DCLK2,CAMK2B1,PRKCHA,ACVR1L,BCKDK,PRKCHB,HYKK.2 |
Interacting Protein
SGMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGMS2.
Bcl7c;AKAP5;TMPO;Tnks2;Fam60a;KIF2C;CENPO
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References
- Yamada, Y; Tian, J; et al. Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells. JOURNAL OF NEUROCHEMISTRY 105:1187-1197(2008).
- Lee, WK; Torchalski, B; et al. ABCB1 Protects Kidney Proximal Tubule Cells Against Cadmium-Induced Apoptosis: Roles of Cadmium and Ceramide Transport. TOXICOLOGICAL SCIENCES 121:343-356(2011).
