SF3B4
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Official Full Name
splicing factor 3b, subunit 4, 49kDa -
Overview
This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. -
Synonyms
SF3B4;splicing factor 3b, subunit 4, 49kDa;splicing factor 3b, subunit 4, 49kD;splicing factor 3B subunit 4;Hsh49;SAP49;SF3b49;MGC10828;Pre mRNA splicing factor SF3b 49 kDa subunit;SAP 49;SF3b50;Spliceosomal protein;Spliceosome associated protein (U2 snRNP);Spliceosome associated protein 49;Spliceosome-associated protein (U2 snRNP);Splicing factor 3b subunit 4 49kDa;spliceosome-associated protein 49;pre-mRNA splicing factor SF3b 49 kDa subunit;pre-mRNA-splicing factor SF3b 49 kDa subunit
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
SF3B4 involved in several pathways and played different roles in them. We selected most pathways SF3B4 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Splicing - Major Pathway | SF3B2,HNRNPR,PTBP1A,PCBP2,PTBP1B,HNRNPUL1,HNRNPH2,HNRNPH1L,PRPF8,RBM5 |
| mRNA processing | CLASRP,HNRNPAB,CELF2,Ankar,RBM4B,PTBP1,RPL36A-HNRNPH2,SNRPN,QK,PTBP2 |
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPL,HNRNPH2,PTBP1A,CSTF1,CSTF2,HNRNPL2,HNRNPH1,PCBP2,CD2BP2,CCAR1 |
| mRNA Splicing | HNRNPH1,HNRNPA2B1,CCAR1,HNRNPL2,RNPC3,ZCRB1,SNRNP35,HNRNPD,HNRNPA0,SF3A3 |
| mRNA Splicing - Minor Pathway | ZCRB1,SNRNP48,SNRNP35,RNPC3,SNRNP25,ZMAT5,YBX1,SF3B2,PDCD7,PRPF8 |
| Gene Expression | COX8A,ZNF713,AIMP2,COX4I1,GTF3C4,POLR3C,ZMAT5,GM3258,ZNF771,IPO8 |
| Spliceosome | HSPA8,NHP2L1A,RBMX,PRPF3,DDX23,HSC70,SNRPD3,SNRPD1,SRSF5B,SRSF1A |
Protein Function
SF3B4 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B4 itself. We selected most functions SF3B4 had, and list some proteins which have the same functions with SF3B4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | FAM133B,OASL,COX4I2,DDX28,SNTB2,SYNE1,PCBP4,MRPS31,DIMT1,BZW1 |
| nucleotide binding | RBM39B,UBE2G1B,KIF5AA,GC2,A1CF,CKMT1,GNA13B,TRIO,ACTB2,EEF1A1B |
| protein binding | HNRNPH3,NDUFA9,FYN,TTC33,HSPA12B,NMNAT1,TCF7L2,TRAPPC6B,RALYL,SMC6 |
Interacting Protein
SF3B4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B4.
TCAF1;NCK2;SS18L1;FRK;MAPK9
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References
- van der Valk, RJP; Kreiner-Moller, E; et al. A novel common variant in DCST2 is associated with length in early life and height in adulthood. HUMAN MOLECULAR GENETICS 24:1155-1168(2015).
- Petit, F; Escande, F; et al. Nager syndrome: confirmation of SF3B4 haploinsufficiency as the major cause. CLINICAL GENETICS 86:246-251(2014).
