SF3B14
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Official Full Name
splicing factor 3B, 14 kDa subunit -
Overview
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. -
Synonyms
SF3B14;splicing factor 3B, 14 kDa subunit;pre-mRNA branch site protein p14;SF3b 14 kDa subunit;spliceosome-associated protein, 14 kDa subunit;P14;Ht006;SAP14;CGI-110;HSPC175;SF3B14a
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SF3B14-1791H | Recombinant Human SF3B14 protein, GST-tagged | E.coli | Human | GST | 1-125 aa | |
| SF3B14-3411H | Recombinant Human SF3B14, His-tagged | E.coli | Human | His |
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| SF3B14-4169R | Recombinant Rhesus monkey SF3B14 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SF3B14-1918HCL | Recombinant Human SF3B14 293 Cell Lysate | HEK293 | Human | Non |
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| SF3B14-3986R | Recombinant Rhesus Macaque SF3B14 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SF3B14-3986R-B | Recombinant Rhesus Macaque SF3B14 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
SF3B14 involved in several pathways and played different roles in them. We selected most pathways SF3B14 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3B14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | TRA2B,U2AF2,MAGOH,DHX38,SNRPB2,SF3A3,BCAS2,THOC2,SMNDC1,RBM22 |
Protein Function
SF3B14 has several biochemical functions, for example, nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3B14 itself. We selected most functions SF3B14 had, and list some proteins which have the same functions with SF3B14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | NADKD1,RMI1,GLULA,MYO1EB,DXO,APLF,ABCB3L1,MYO6A,SCAF8,RBMY1F |
| poly(A) RNA binding | ATXN2L,MKRN1,CRNKL1,PCBP1,SRP54,RBMX,NQO1,STRBP,MAPRE1,KHDRBS1 |
Interacting Protein
SF3B14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3B14 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3B14.
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References
- Paun, BC; Kukuruga, D; et al. Relation Between Normal Rectal Methylation, Smoking Status, and the Presence or Absence of Colorectal Adenomas. CANCER 116:4495-4501(2010).
