SF3A3
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Official Full Name
splicing factor 3a, subunit 3, 60kDa -
Overview
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. -
Synonyms
SF3A3;splicing factor 3a, subunit 3, 60kDa;splicing factor 3a, subunit 3, 60kD;splicing factor 3A subunit 3;PRP9;PRPF9;SAP61;SF3a60;Pre mRNA splicing factor SF3a (60kD);Pre mRNA splicing factor SF3a;PRP 9;PRPF 9;SAP 61;Spliceosome associated protein 61;Splicing factor 3a subunit 3 60kDa;OTTHUMP00000004730;spliceosome-associated protein 61;pre-mRNA splicing factor SF3a (60kD)
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SF3A3-2612H | Recombinant Human SF3A3, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| SF3A3-1235Z | Recombinant Zebrafish SF3A3 | Mammalian Cell | Zebrafish | His |
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| SF3A3-30078TH | Recombinant Human SF3A3, His-tagged | E.coli | Human | His | 97-501 a.a. |
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| SF3A3-1919HCL | Recombinant Human SF3A3 293 Cell Lysate | HEK293 | Human | Non |
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| Sf3a3-5809M | Recombinant Mouse Sf3a3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SF3A3-6161H | Recombinant Human SF3A3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
SF3A3 involved in several pathways and played different roles in them. We selected most pathways SF3A3 participated on our site, such as Diurnally regulated genes with circadian orthologs,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Processing of Capped Intron-Containing Pre-mRNA | HNRNPA0,ZMAT5,YBX1,SNRNP25,HNRNPH2,BCAS2,HNRNPR,PCBP2,HNRNPA2B1,THOC4 |
| Gene Expression | RXRBB,TCEB3,HNRNPUL1,DNMT3B,ZNF461,ZNF254,PEAK1,CTDP1,HIPK1,TSEN2 |
| Diurnally regulated genes with circadian orthologs | QKI,NCKAP1,DAZAP2,QK,MYF6,KLF9,NR1D2,RBPMS,CEBPB,CBX3 |
| mRNA processing | SREK1,RAVER1,CLK1,ZFP830,DDX20,OASL2,PTBP2,ZFP622,TXNL4A,PRPF8 |
| mRNA Splicing - Major Pathway | HNRNPH2,PTBP1B,HNRNPF,PTBP1A,HNRNPA2B1,HNRNPH1,PTBP1,HNRNPR,HNRNPL,HNRNPD |
| Spliceosome | LSM5,SRSF7,SNRNP200,SNRNP70,PRPF38A,SNW1,DDX42,U2AF2B,ZMAT2,PRPF19 |
| mRNA Splicing | ZCRB1,SNRNP25,SNRNP48,HNRNPF,HNRNPA0B,HNRNPA0A,SF3A1,HNRNPH1L,SNRNP35,PTBP1B |
Protein Function
SF3A3 has several biochemical functions, for example, poly(A) RNA binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3A3 itself. We selected most functions SF3A3 had, and list some proteins which have the same functions with SF3A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GAN,HADHB,DNAJB6,SENP3,FAM195A,PLA2G16,MOXD1,RHOC,AKAP1,PITPNM1 |
| zinc ion binding | TRIM21,TRIM43A,LONRF1L,BMI1B,GATAD2AB,MBD1,S100A9,CSRP1A,MYLIPB,NR5A1 |
| poly(A) RNA binding | RPL31,RPL26,ERI3,NSUN2,CLNS1A,SAMSN1,DUSP14,LGALS1,CRNKL1,XRCC5 |
Interacting Protein
SF3A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3A3.
TADA2A;TRIM69;ORF;ZNF212;HSPB1;SF3A1;WBP4;SMNDC1;FOS;CHM
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