SF3A2
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Official Full Name
splicing factor 3a, subunit 2, 66kDa -
Overview
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. -
Synonyms
SF3A2;splicing factor 3a, subunit 2, 66kDa;splicing factor 3a, subunit 2, 66kD;splicing factor 3A subunit 2;Prp11;PRPF11;SAP62;SF3a66;Spliceosome-associated protein 62;SAP 62;spliceosome associated protein 62;pre-mRNA splicing factor SF3A, subunit 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SF3A2-2611H | Recombinant Human SF3A2, His-tagged | E.coli | Human | His | 118-464aa | |
| SF3A2-11273Z | Recombinant Zebrafish SF3A2 | Mammalian Cell | Zebrafish | His |
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| SF3A2-1215C | Recombinant Chicken SF3A2 | Mammalian Cell | Chicken | His |
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| SF3A2-5351R | Recombinant Rat SF3A2 Protein | Mammalian Cell | Rat | His |
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| SF3A2-5010R | Recombinant Rat SF3A2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SF3A2-5010R-B | Recombinant Rat SF3A2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SF3A2 involved in several pathways and played different roles in them. We selected most pathways SF3A2 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with SF3A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SNRPA,SNRPB,HNRNPA1,SRSF1A,HNRNPM,SRSF1,SF3A1,DHX16,THOC3,SNRNP40 |
Protein Function
SF3A2 has several biochemical functions, for example, poly(A) RNA binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SF3A2 itself. We selected most functions SF3A2 had, and list some proteins which have the same functions with SF3A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FDX1L,CD160,NUF2,SEC63,FAM128B,C1orf216,TEAD1,FLT3,IL17F,PRELID1 |
| zinc ion binding | USP33,MSRB2,ASTL,ING4,PHF23A,PHF14,ESR2B,RNF121,SHPRH,ZNRF1 |
| poly(A) RNA binding | LGALS3,C1orf53,TBRG4,MTHFSD,Cstb,TFRC,PRPF4B,XRCC6,NOC2L,OASL |
Interacting Protein
SF3A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SF3A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SF3A2.
SF3A1;DHX15;SF1;CDC5L;nm_004500.2;nm_006387.4;nm_014281.3;nm_016403.2;nm_018011.2;nm_033537.1;nm_144604.2;TCERG1;SART1;HNRNPR;PRPF3
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References
- Hirokawa, M; Morita, H; et al. A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. EUROPEAN JOURNAL OF HUMAN GENETICS 23:374-380(2015).
- Maitra, R; Sadofsky, MJ; et al. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified proteinprotein interactions. NUCLEIC ACIDS RESEARCH 37:3301-3309(2009).
