SETDB2
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Official Full Name
SET domain, bifurcated 2 -
Overview
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008] -
Synonyms
SETDB2;SET domain, bifurcated 2;CLLD8;CLLL8;KMT1F;C13orf4;histone-lysine N-methyltransferase SETDB2;lysine N-methyltransferase 1F;chronic lymphocytic leukemia deletion region 8;chronic lymphocytic leukemia deletion region gene 8 protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SETDB2-11790Z | Recombinant Zebrafish SETDB2 | Mammalian Cell | Zebrafish | His |
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| SETDB2-14987M | Recombinant Mouse SETDB2 Protein | Mammalian Cell | Mouse | His |
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| SETDB2-1632H | Recombinant Human SET Domain, Bifurcated 2, GST-tagged | Sf9 Insect Cell | Human | GST |
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| SETDB2-6965H | Recombinant Human SETDB2, GST-tagged | Sf9 Insect Cell | Human | GST | Full length |
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| SETDB2-8072M | Recombinant Mouse SETDB2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SETDB2-8072M-B | Recombinant Mouse SETDB2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SETDB2 involved in several pathways and played different roles in them. We selected most pathways SETDB2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | SETDB1,GCDH,ALDH7A1,HYKK.2,EHMT1A,KMT2A,SETD8B,WHSC1,HADHA,ALDH3A2 |
Protein Function
SETDB2 has several biochemical functions, for example, DNA binding,histone methyltransferase activity (H3-K9 specific),protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETDB2 itself. We selected most functions SETDB2 had, and list some proteins which have the same functions with SETDB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NR1H2,POLE3,ZNF454,SHPRH,EME1,MEF2CB,ASXL3,HOXD11A,SIX7,MXI1 |
| histone methyltransferase activity (H3-K9 specific) | SUV39H2,EHMT1,EHMT2,SUV39H1 |
| zinc ion binding | GATA4,CALR,CA13,L3MBTL1,LDB3A,MMP1,PRICKLE2A,RNF166,UBR5,SETDB1B |
| protein binding | GAPDHS,PRDM5,C8orf74,S100A7,LBR,BECN1,STAMBP,MIS18BP1,MAP4K5,FNTA |
Interacting Protein
SETDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETDB2.
ARL14EP;IGHG1
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References
- Racz, I; et al. Stationary black holes as holographs II. CLASSICAL AND QUANTUM GRAVITY 31:-(2014).
- Ideno, H; Shimada, A; et al. Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. GENE EXPRESSION PATTERNS 13:84-90(2013).
