SETD6
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Official Full Name
SET domain containing 6 -
Synonyms
SETD6;SET domain containing 6;N-lysine methyltransferase SETD6;FLJ21148;SET domain-containing protein 6
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- GST
- His
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SETD6 involved in several pathways and played different roles in them. We selected most pathways SETD6 participated on our site, such as Activation of SMO,Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Other | GPR77,GPR55,CELSR3,GPR143,VMN1R44,VMN1R43,S1PR1,GPR17,OR3A4P,GPR176 |
| Basal cell carcinoma | TCF7L2,WNT9A,WNT8B,TCF7,PTCH2,FZD2,WNT5B,TRP53,WNT5A,FZD8 |
| Class B/2 (Secretin family receptors) | CRH,PTHLH,RAMP2,CRHB,PTH2,PTHRP2,ADM,PTHLHA,CRHR1,FZD10 |
| GPCR ligand binding | INSL3,CCL35.1,EDN1,ADM,OPN1SW1,OXTRL,OPN1MW2,ADRA2B,ANXA1,HEBP1 |
| BBSome-mediated cargo-targeting to cilium | BBS1,BBS5,SSTR3,CCT8,PROL1,BBS9,CCT2,LZTFL1,BBS7,BBS4 |
| Activation of SMO | CDON,EFCAB7,EVC,CSNK1A1,GAS8,BOC,IQCE,KIF3A,ADRBK1,EVC2 |
| Assembly of the primary cilium | DYNLRB1,IFT74,TTC30A,PKD1,CLASP1A,AKAP9,WDR19,DYF-1,SCLT1,BBS5 |
| Cargo trafficking to the periciliary membrane | BBS1,CCT2,UNC119B,RP2,CCT4,LZTFL1,BBS2,NPHP3,ARL3,ARL13B |
Protein Function
SETD6 has several biochemical functions, for example, G-protein coupled receptor activity,NOT Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD6 itself. We selected most functions SETD6 had, and list some proteins which have the same functions with SETD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| patched binding | Shh,SMO,IHH,PTCH1,CAV1,CCNB1,BBS1,DHH |
| Wnt-protein binding | ROR1,SMO,FZD7A,FZD8A,WLS,LRP6,SFRP4,SFRP1,FZD3A,FZD9B |
| G-protein coupled receptor activity | ADRA1BB,FZD3A,OLFR488,OR10C1,VMN1R50,RPA1,OLFR492,APLNRA,TAAR14G,VMN1R48 |
| drug binding | PPARG,HMGB2,FOLR1,ADRB2,CHRNA2,SRP54,ACE,DHODH,PIGC,DHFR |
| NOT Wnt-activated receptor activity | SFRP1A,SFRP4,SFRP1B,FRZB,TSPAN12,SFRP1,SZL,SMO,SFRP2 |
| protein binding | CCDC64,ACTA1,CSRP2,NUDT18,NRADD,ABCE1,WIPI2,EMP3,LILRB2,CRIPAK |
Interacting Protein
SETD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD6.
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References
- Yu, Y; Lasanajak, Y; et al. Human Milk Contains Novel Glycans That Are Potential Decoy Receptors for Neonatal Rotaviruses. MOLECULAR & CELLULAR PROTEOMICS 13:2944-2960(2014).
- Back, JW; Frisch, C; et al. Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin. PROTEIN ENGINEERING DESIGN & SELECTION 25:251-259(2012).
