SETD3
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Official Full Name
SET domain containing 3 -
Synonyms
SETD3;SET domain containing 3;C14orf154, chromosome 14 open reading frame 154;histone-lysine N-methyltransferase setd3;FLJ23027;SET domain-containing protein 3;C14orf154;MGC87236;DKFZp761E1415
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SETD3 involved in several pathways and played different roles in them. We selected most pathways SETD3 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,PKMTs methylate histone lysines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | C17orf81,KANSL2,SUZ12B,PRDM16,SAP130,KAT5,KAT6A,YEATS4,RBBP4,KAT8 |
| Chromatin organization | MTA1,KAT6A,KDM5B,PADI1,GATAD2A,KDM2A,TADA2A,MTA3,SMARCC1,KDM1A |
| PKMTs methylate histone lysines | ASH2L,PRDM16,RBBP5,SUZ12B,SUZ12,EHMT2,DPY30,SUZ12A,AEBP2,SMYD2A |
Protein Function
SETD3 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,histone methyltransferase activity (H3-K36 specific),histone methyltransferase activity (H3-K4 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by SETD3 itself. We selected most functions SETD3 had, and list some proteins which have the same functions with SETD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone methyltransferase activity (H3-K36 specific) | SMYD2B,NSD1,SETD2,ASH1L,SMYD2,SETMAR,SMYD2A |
| transcription coactivator activity | FHL5,E4F1,MED16,SRA1,TFAP2A,SMARCA2,NR1H3,GTF2A2,EP300,SNW1 |
| histone methyltransferase activity (H3-K4 specific) | SMYD1B,MLL1,SETMAR,WDR82,KMT2A,KMT2E,MLL5,ASH1L,WBP7,WHSC1L1 |
| RNA polymerase II activating transcription factor binding | SMAD3,TBX6,ZFPM1,TBX20,PITX2,MAD2L2,TP53BP1,HNF4A,EOMES,RB1 |
Interacting Protein
SETD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD3.
SRPK1;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;cona_canen
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References
- Elf, K; Sheuchenko, G; et al. Alterations in muscle proteome of patients diagnosed with amyotrophic lateral sclerosis. JOURNAL OF PROTEOMICS 108:55-64(2014).
- Fabi, A; Mottolese, M; et al. Therapeutic targeting of ERBB2 in breast cancer: understanding resistance in the laboratory and combating it in the clinic. JOURNAL OF MOLECULAR MEDICINE-JMM 92:681-695(2014).
