SESN1
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Official Full Name
sestrin 1 -
Overview
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
SESN1;sestrin 1;sestrin-1;PA26;SEST1;AU044290;MGC142129;RP11-787I22.1;1110002G11Rik;MGC118148;MGC138241;OTTMUSP00000022799;p53 regulated PA26 nuclear protein;p53 regulated protein PA26;p53-regulated protein PA26;SESN1_HUMAN;OTTHUMP00000016951;OTTHUMP00000016952;OTTHUMP00000016953;p53 activated gene 26
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SESN1-2604H | Recombinant Human SESN1, GST-tagged | E.coli | Human | GST | 1-141aa | |
| Sesn1-358M | Recombinant Mouse Sesn1 Protein, His-tagged | E.coli | Mouse | His | Gly45~Thr492 | |
| SESN1-14972M | Recombinant Mouse SESN1 Protein | Mammalian Cell | Mouse | His |
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| SESN1-770Z | Recombinant Zebrafish SESN1 | Mammalian Cell | Zebrafish | His |
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| SESN1-1585HCL | Recombinant Human SESN1 cell lysate | Human | Non |
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| SESN1-8063M | Recombinant Mouse SESN1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SESN1-8063M-B | Recombinant Mouse SESN1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SESN1 involved in several pathways and played different roles in them. We selected most pathways SESN1 participated on our site, such as p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SESN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| p signaling pathway | COP1,BIDA,RFWD2,RPRMA,MDM4,ATM,TP53I3,TSC2,TP53,GADD45BA |
Protein Function
SESN1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SESN1 itself. We selected most functions SESN1 had, and list some proteins which have the same functions with SESN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SESN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SESN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SESN1.
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