SERPINA6
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Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 -
Overview
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. -
Synonyms
SERPINA6;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6;CBG, serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 6;corticosteroid-binding globulin;corticosteroid binding globulin;transcortin;CBG;CBG_HUMAN;serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6;Serpin A6;serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6;OTTHUMP00000245861;serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
Recombinant Proteins
- Human
- Mouse
- Pig
- Rat
- HEK293
- Yeast
- E.coli
- Wheat Germ
- Mammalian Cell
- Human Cell
- Rabbit
- Goat
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- GST
- His&Avi
- His&Fc&Avi
Involved Pathway
SERPINA6 involved in several pathways and played different roles in them. We selected most pathways SERPINA6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SERPINA6 has several biochemical functions, for example, serine-type endopeptidase inhibitor activity,steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA6 itself. We selected most functions SERPINA6 had, and list some proteins which have the same functions with SERPINA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| steroid binding | PAQR7,CYP21A1,PAQR5,ESRRA,ESRRG,PAQR8,ESRRB,ESR1,ESR2B,ESRRGB |
| serine-type endopeptidase inhibitor activity | CD109,AGT,SERPINA1,SERPINA1L,SERPINI1,SERPINA12,SERPINB1L1,Serpina1c,SERPINA3,SERPINB8 |
Interacting Protein
SERPINA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA6.
Resources
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References
- Shen, N; Gong, J; et al. Integrative Genomic Analysis Identifies That SERPINA6-rs1998056 Regulated by FOXA/ER alpha Is Associated with Female Hepatocellular Carcinoma. PLOS ONE 9:-(2014).
- Bolton, JL; Hayward, C; et al. Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. PLOS GENETICS 10:-(2014).
