SEPT5
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Official Full Name
septin 5 -
Overview
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. -
Synonyms
SEPT5;septin 5;peanut like 1 (Drosophila);PNUTL1;septin-5;H5;HCDCREL 1;5 Sep;CDCrel 1;CDCREL;CDCrel-1;CDCREL1;Cell division control related protein 1;Cell division control-related protein 1;H5;HCDCREL 1;OTTHUMP00000197271;OTTHUMP00000197272;OTTHUMP00000197273;OTTHUMP00000197274;OTTHUMP00000197275;OTTHUMP00000197276;OTTHUMP00000197396;OTTHUMP00000197410;Peanut like 1;Peanut like 1 homolog;Peanut like protein 1;Peanut-like protein 1;Platelet glycoprotein Ib beta chain;PNUTL1;SEPT5;SEPT5_HUMAN;Septin 5;Septin-5;peanut-like 1;platelet glycoprotein Ib beta chain;cell division control related protein 1;CDCREL;PNUTL1;CDCREL1;CDCREL-1;HCDCREL-1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- His&GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SEPT5-356H | Recombinant Human SEPT5 Protein, His-tagged | E.coli | Human | His | Ser77~Ser323 | |
| SEPT5-14895M | Recombinant Mouse SEPT5 Protein | Mammalian Cell | Mouse | His |
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| SEPT5-2360C | Recombinant Chicken SEPT5 | Mammalian Cell | Chicken | His |
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| SEPT5-30597TH | Recombinant Human SEPT5, HIS-tagged | E.coli | Human | His | 369 amino acids |
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| SEPT5-30599TH | Recombinant Human SEPT5, HIS-tagged | E.coli | Human | His | 369 amino acids |
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| SEPT5-31398TH | Recombinant Human SEPT5, HIS-tagged | E.coli | Human | His | 14-369 a.a. |
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| SEPT5-3591H | Recombinant Human SEPT5, His-tagged | E.coli | Human | His |
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| SEPT5-5249H | Recombinant Human SEPT5 Protein, GST/His-tagged | E.coli | Human | His&GST | 1-369 a.a. |
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| SEPT5-5327R | Recombinant Rat SEPT5 Protein | Mammalian Cell | Rat | His |
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| SEPT5-1957HCL | Recombinant Human SEPT5 293 Cell Lysate | HEK293 | Human | Non |
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| SEPT5-4986R | Recombinant Rat SEPT5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SEPT5-4986R-B | Recombinant Rat SEPT5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SEPT5-8027M | Recombinant Mouse SEPT5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SEPT5-8027M-B | Recombinant Mouse SEPT5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SEPT5 involved in several pathways and played different roles in them. We selected most pathways SEPT5 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | GNAI3,UCHL1,NDUFA13,LRRK2,COX6B2,NDUFA12,UQCRC2,NDUFA10,UQCRC1,PPIF |
Protein Function
SEPT5 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT5 itself. We selected most functions SEPT5 had, and list some proteins which have the same functions with SEPT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CRLF3,PARN,CHERP,CHDH,DDX11,ARHGEF12,DPH2,SMNDC1,PTPN18,SERPINB8 |
| structural molecule activity | CLDN2,ISCA1,KRT84,SPRR1B,SPRR2H,CLDN11B,SNTB2,CLDN10B,CLDN23,LCE1F |
| GTP binding | PCK2,MFN1B,RNGTT,GUCY2E,RAB36,DNM1A,RAP2C,NKIRAS1,GNA11,GNAO1 |
| GTPase activity | RAB11AL,TUBG1,GTPBP5,RAB21,EFTUD1,RAB5B,RAB3AB,DNM1L,RABL5,GTPBP1L |
Interacting Protein
SEPT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT5.
SEPT11;SEPT10;SEPT6;SEPT2;SEPT1
Resources
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References
- Zeraik, AE; Rinaldi, G; et al. Septins of Platyhelminths: Identification, Phylogeny, Expression and Localization among Developmental Stages of Schistosoma mansoni. PLOS NEGLECTED TROPICAL DISEASES 7:-(2013).
- Tsang, CW; Estey, MP; et al. Characterization of presynaptic septin complexes in mammalian hippocampal neurons. BIOLOGICAL CHEMISTRY 392:739-749(2011).
