SEPT4

  • Official Full Name

    septin 4

  • Overview

    This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]

  • Synonyms

    SEPT4;septin 4;H5;ARTS;MART;SEP4;CE5B3;PNUTL2;hucep-7;BRADEION;hCDCREL-2;septin-4;septin-M;CE5B3 beta;bradeion beta;brain protein H5;cerebral protein 7;peanut-like protein 2;cell division control-related protein 2;apoptosis-related protein in the TGF-beta signaling pathway

Recombinant Proteins

  • Mouse
  • Cynomolgus
  • Human
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi

    Involved Pathway

    SEPT4 involved in several pathways and played different roles in them. We selected most pathways SEPT4 participated on our site, such as Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis Modulation and Signaling BOK,BCL2L11,DAXX,HRK,BIK,DFFA,BAG3,CRADD,CAPNS1,CDKN2A

    Protein Function

    SEPT4 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT4 itself. We selected most functions SEPT4 had, and list some proteins which have the same functions with SEPT4. You can find most of the proteins on our site.

    Function Related Protein
    structural molecule activity CLDNG,COPB1,PGM5,CLDNF,KRT25,KRT1,MAP2,CLDNK,EVPLA,SPRR2E
    GTP binding SEPT5A,GNA11B,ARL1,NME1,RAB33B,GNAI2,SAR1A,RAB19,RHEBL1,TUBG1
    GTPase activity RAB41,EEF2B,RAB5AB,RAB7,GNA13,SAR1B,GNG5,EEF1A2,RAB40AL,RAB40B
    protein binding RTN4R,GNG4,RUNX3,MKI67IP,PSMB9,RPA2,TMEM8B,DPM1,CAMKK1,NPBWR1

    Interacting Protein

    SEPT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT4.

    RB1;NR4A1;SIAH1;TNIK;SEPT14;SEPT12;Caskin1

    Resources

    References

    • Hosseinifar, H; Shafipour, M; et al. Relationship between absence of annulus and asthenozoospermia in Iranian men. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 31:1681-1685(2014).
    • Guan, JK; Kinoshita, M; et al. Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development. BMC DEVELOPMENTAL BIOLOGY 9:-(2009).

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