SEPSECS

  • Official Full Name

    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

  • Overview

    Autoimmune hepatitis (AIH) is a chronic progressive liver disease of unknown origin that responds well to immunosuppressive therapy, but has a poor prognosis if untreated. Early and accurate diagnosis is therefore of great importance. AIH is characterized by histological features of periportal hepatitis in the absense of viral markers, by hypergammaglobulinemia and, in the majority of patients, by the presence of autoantibodies in serum. 70% of all patients have significant titres of anti-nuclear antibodies (ANA), smooth-muscle autoantibodies (SMA) or liver-kidney microsomal autoantibodies (LKM). These antibodies are of diagnostic value for AIH, but not specific for the disease since they also occur in 10-15% of patients with viral hepatitis and other immune-mediated diseases. In contrast, antibodies to soluble liver antigen (SLA) and antibodies to a liver and pancreas antigen (LP) are the only to be specific for autoimmune hepatitis and are present in 20% of all AIH-patients, many of whom are negative for other autoantibodies. It was shown that anti-SLA and anti-LP are directed against the same antigen and thus are identical. The SLA/LP antigen cloned and sequenced in 2000 is a protein of unknown function, suggested to be an UGA-suppressor tRNA-associated protein. ANA/SMA and anti-SLA positive patients share most clinical, biochemical, histological and prognostic features. Distinction of different subgroups according to autoantibody status is therefore clinically not helpful. However, testing for anti-SLA autoantibodies is very important for the diagnosis of AIH in many patients who are negative for other autoantibodies and may otherwise be misdiagnosed.

  • Synonyms

    SEPSECS;Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Chicken
  • E.coli
  • Mammalian Cell
  • HEK293
  • Yeast
  • GST
  • His
  • Non
  • His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
SEPSECS-2580H Recombinant Human SEPSECS, GST-tagged E.coli Human GST C-term-306aa
SEPSECS-10501Z Recombinant Zebrafish SEPSECS Mammalian Cell Zebrafish His
SEPSECS-14889M Recombinant Mouse SEPSECS Protein Mammalian Cell Mouse His
SEPSECS-162H Recombinant Human SEPSECS Protein, His-tagged E.coli Human His
SEPSECS-2828C Recombinant Chicken SEPSECS Mammalian Cell Chicken His
SEPSECS-931H Recombinant Human SEPSECS, His-tagged E.coli Human His
SEPSECS-1968HCL Recombinant Human SEPSECS 293 Cell Lysate HEK293 Human Non
SEPSECS-2322H Recombinant Human SEPSECS protein, His-tagged Yeast Human His 1-501aa
SEPSECS-290H Recombinant Human SEPSECS Protein, His-tagged(N-Terminus) E.coli Human His 1-501
SEPSECS-6854H Recombinant Human SEPSECS protein, His&Myc-tagged E.coli Human His&Myc 1-501a.a.
SEPSECS-8022M Recombinant Mouse SEPSECS Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
SEPSECS-8022M-B Recombinant Mouse SEPSECS Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SEPSECS involved in several pathways and played different roles in them. We selected most pathways SEPSECS participated on our site, such as Selenocompound metabolism,Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPSECS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Selenocompound metabolism SPS2,SEPHS1,PAPSS2A,MARS2,MARS,INMT,CCBL2,PSTK,TXNRD2,MTR
    Aminoacyl-tRNA biosynthesis DARS,YARS,NARS2,PET112L,MTFMT,TARS,EPRS,FARSB,SARS2,RARS

    Protein Function

    SEPSECS has several biochemical functions, for example, protein binding,tRNA binding,transferase activity, transferring selenium-containing groups. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPSECS itself. We selected most functions SEPSECS had, and list some proteins which have the same functions with SEPSECS. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TUBA3C,CORO6,SLC35F6,PTPRS,KLF6,RAB7L1,KHDRBS1,CALCR,BCL2L10,POLD4
    tRNA binding EARS2,TRMT1,FARSA,XPOT,PTCD1,AARS2,THG1L,FDXACB1,NSUN2,IGHMBP2

    Interacting Protein

    SEPSECS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPSECS here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPSECS.

    gag;gag;YBX1

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