SENP5

  • Official Full Name

    SUMO1/sentrin specific peptidase 5

  • Overview

    The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see;SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are;responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the;conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO;conjugates (Di Bacco et al., 2006 (PubMed 16738315)).

  • Synonyms

    SENP5;SUMO1/sentrin specific peptidase 5;SUMO1/sentrin specific protease 5;sentrin-specific protease 5;MGC27076;sentrin/SUMO-specific protease SENP5;FLJ42398;DKFZp564O1016

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Zebrafish
  • Cynomolgus
  • Human
  • Mammalian Cell
  • HEK293
  • E.coli
  • His
  • Non
  • GST
  • His&Fc&Avi

    Involved Pathway

    SENP5 involved in several pathways and played different roles in them. We selected most pathways SENP5 participated on our site, such as Metabolism of proteins,Post-translational protein modification,Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SENP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins IGFBP1A,PFDN5,SLC30A8,COX17,TRAPPC1,LMCD1,INHA,MGAT4B,SAE1,SPON2
    Post-translational protein modification TMED2,ARSJ,MLEC,B3GNT6,CNIH2,RNF2,GALNT5,ARSH,NAPG,PIGK
    SUMO is proteolytically processed SENP1
    SUMOylation SMC5,CBX8,PHC2,NSMCE1,RNF2,NSMCE4A,EID3,SAE1,UBA2,NSMCE2
    Processing and activation of SUMO UBA2,SAE1,SENP1

    Protein Function

    SENP5 has several biochemical functions, for example, SUMO-specific protease activity,endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SENP5 itself. We selected most functions SENP5 had, and list some proteins which have the same functions with SENP5. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SULT1E1,HELZ2,USP8,C1QTNF2,SPTAN1,YWHAZ,KRT33B,NITR9,ZUFSP,KRT6B
    endopeptidase activity HTRA4,PSMA3,TPP2,MMP1A,PSEN1,ECE1,PSMA4,KLK1B22,CPS1,PSMA5
    SUMO-specific protease activity SENP1,SENP3B,SENP6,SENP3,SENP3A

    Interacting Protein

    SENP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SENP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SENP5.

    ESR1

    Resources

    References

    • Kim, EY; Zhang, Y; et al. SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 78:154-164(2015).
    • Wang, K; Zhang, XC; et al. Inhibition of SENP5 suppresses cell growth and promotes apoptosis in osteosarcoma cells. EXPERIMENTAL AND THERAPEUTIC MEDICINE 7:1691-1695(2014).

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