SEMA4B
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Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -
Overview
Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene. -
Synonyms
SEMA4B;sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B;SEMAC;semaphorin-4B;KIAA1745;MGC131831;SemC;Sema domain immunoglobulin domain (Ig) transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 4B;Sema domain immunoglobulin domain (Ig) transmembrane domain (TM) and short cytoplasmic domain 4B;Semaphorin 4B;sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- His&Fc
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SEMA4B involved in several pathways and played different roles in them. We selected most pathways SEMA4B participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EPHA6,L1CAM,AKAP9,COL9A3,SDCBP,PAK7,ARHGEF12,UNC5A,DPYSL5A,FGFR1B |
Protein Function
SEMA4B has several biochemical functions, for example, chemorepellent activity,NOT neuropilin binding,semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA4B itself. We selected most functions SEMA4B had, and list some proteins which have the same functions with SEMA4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT neuropilin binding | SEMA4D,SEMA4A,SEMA4C,SEMA4BA |
| chemorepellent activity | SEMA6A,SEMA3BL,FLRT3,EFNA5,SEMA3AA,SEMA3FA,Sema3f,SEMA3A,SEMA3C,SEMA6E |
| semaphorin receptor binding | SEMA3AB,SEMA4C,SH3BGRL3,SEMA4E,SEMA3A,SEMA3D,SEMA3G,SEMA6DL,SEMA5A,SEMA3E |
Interacting Protein
SEMA4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA4B here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA4B.
Resources
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References
- Jian, H; Zhao, Y; et al. SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer. TUMOR BIOLOGY 35:11051-11056(2014).
- Jian, H; Liu, B; et al. Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion. TUMOR BIOLOGY 35:4949-4955(2014).
